A case of presumptive primary lateral sclerosis with upper and lower motor neurone pathology

Simple item page
dc.contributor.authorShort, C.
dc.contributor.authorScott, G.
dc.contributor.authorBlumbergs, P.
dc.contributor.authorKoblar, S.
dc.date.issued2005
dc.descriptionCopyright © 2005 Published by Elsevier Ltd.
dc.description.abstractMotor Neurone Disease (MND) is one of the commonest neurodegenerative disorders of adulthood. MND characteristically presents with a combination of both upper and lower motor neurone features. Primary Lateral Sclerosis (PLS) is thought to be a variant of MND presenting with purely upper motor neurone signs. Debate continues over whether PLS constitutes a distinct pathological entity or whether it is part of the spectrum of motor neurone diseases that present as an upper motor neurone-predominant form of MND. We present a case of MND with purely upper motor neurone features and a prominent pain component. A pre-mortem diagnosis of PLS was made, however autopsy findings demonstrated both upper and lower motor neurone involvement. We believe these findings support the view that PLS is not a discrete pathological entity, but that it is a part of the range of motor neurone diseases that present with predominant but not exclusive upper motor neurone involvement. This case also highlights the feature that pain may be associated with MND even though it is not appreciated to have a sensory pathology.
dc.description.statementofresponsibilityCathy L. Short, Grace Scott, Peter C. Blumbergs and Simon A. Koblar
dc.identifier.citationJournal of Clinical Neuroscience, 2005; 12(6):706-709
dc.identifier.doi10.1016/j.jocn.2004.08.032
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.orcidKoblar, S. [0000-0002-8667-203X]
dc.identifier.urihttp://hdl.handle.net/2440/17162
dc.language.isoen
dc.publisherChurchill Livingstone
dc.source.urihttps://doi.org/10.1016/j.jocn.2004.08.032
dc.subjectprimary lateral sclerosis
dc.subjectmotor neurone disease
dc.subjectpain
dc.titleA case of presumptive primary lateral sclerosis with upper and lower motor neurone pathology
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Pathology publications