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CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells

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dc.contributor.authorZhang, Y.
dc.contributor.authorZhu, G.
dc.contributor.authorXiao, H.
dc.contributor.authorLiu, X.
dc.contributor.authorHan, G.
dc.contributor.authorChen, G.
dc.contributor.authorHou, C.
dc.contributor.authorShen, B.
dc.contributor.authorLi, Y.
dc.contributor.authorMa, N.
dc.contributor.authorWang, R.
dc.date.issued2017
dc.description.abstractAs the first line of defence, marginal zone (MZ) B cells play principal roles in clearing blood‐borne pathogens during infection and are over‐primed in autoimmune diseases. However, the basic mechanisms underlying MZ B‐cell development are still unclear. We found here that CD19 deficiency blocked the differentiation of marginal zone precursors (MZP) to MZ B cells, whereas CD19 expression in CD19‐deficient MZP rescues MZ B‐cell generation. Furthermore, CD19 regulates Notch2 cleavage by up‐regulating ADAM28 expression in MZP. Finally, we found that CD19 suppressed Foxo1 expression to promote ADAM28 expression in MZP. These results suggest that CD19 controls the differentiation of MZP to MZ B cells by regulating ADAM28‐mediated Notch2 cleavage. Thus, we demonstrated the basic mechanisms underlying the differentiation of MZP to MZ B cells.
dc.description.statementofresponsibilityYu Zhang, Gaizhi Zhu, He Xiao, Xiaoling Liu, Gencheng Han, Guojiang Chen, Chunmei Hou, Beifen Shen, Yan Li, Ning Ma, Renxi Wang
dc.identifier.citationJournal of Cellular and Molecular Medicine, 2017; 21(12):3658-3669
dc.identifier.doi10.1111/jcmm.13276
dc.identifier.issn1582-1838
dc.identifier.issn1582-4934
dc.identifier.urihttp://hdl.handle.net/2440/113960
dc.language.isoen
dc.publisherWiley
dc.relation.grant2013CB530506
dc.relation.grant2015CB553704
dc.relation.grant81471529
dc.relation.grant81401332
dc.relation.grant81272320
dc.relation.grant81471540
dc.relation.grant81472647
dc.rights© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1111/jcmm.13276
dc.subjectCD19; marginal zone precursors; MZ B cells; Notch2; ADAM28; Foxo1
dc.titleCD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells
dc.typeJournal article
pubs.publication-statusPublished

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