Effects of coating materials and processing conditions on flow enhancement of cohesive acetaminophen powders by high-shear processing with pharmaceutical lubricants
Files
(Published version)
Date
2017
Authors
Wei, G.
Mangal, S.
Denman, J.
Gengenbach, T.
Lee Bonar, K.
Khan, R.I.
Qu, L.
Li, T.
Zhou, Q.T.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Pharmaceutical Sciences, 2017; 106(10):3022-3032
Statement of Responsibility
Conference Name
Abstract
This study has investigated the surface coating efficiency and powder flow improvement of a model cohesive acetaminophen powder by high-shear processing with pharmaceutical lubricants through 2 common equipment, conical comil and high-shear mixer. Effects of coating materials and processing parameters on powder flow and surface coating coverage were evaluated. Both Carr's index and shear cell data indicated that processing with the lubricants using comil or high-shear mixer substantially improved the flow of the cohesive acetaminophen powder. Flow improvement was most pronounced for those processed with 1% wt/wt magnesium stearate, from "cohesive" for the V-blended sample to "easy flowing" for the optimally coated sample. Qualitative and quantitative characterizations demonstrated a greater degree of surface coverage for high-shear mixing compared with comilling; nevertheless, flow properties of the samples at the corresponding optimized conditions were comparable between 2 techniques. Scanning electron microscopy images demonstrated different coating mechanisms with magnesium stearate or l-leucine (magnesium stearate forms a coating layer and leucine coating increases surface roughness). Furthermore, surface coating with hydrophobic magnesium stearate did not retard the dissolution kinetics of acetaminophen. Future studies are warranted to evaluate tableting behavior of such dry-coated pharmaceutical powders.
School/Discipline
Dissertation Note
Provenance
Description
Data source: supplementary data, https://doi.org/10.1016/j.xphs.2017.05.020
Access Status
Rights
Copyright 2017 American Pharmacists Association. Published by Elsevier
Access Condition Notes: Postprint available after 1 July 2018