The role of haptenation in penicillin and cephalosporin allergy /
Files
(Published version)
Date
2019
Authors
Vareeckal-Joseph, Sherin,
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
thesis
Citation
Statement of Responsibility
Conference Name
Abstract
Current in vitro diagnostic tests for potentially fatal immediate hypersensitivity reactions to penicillins and cephalosporins lack sensitivity and utilise covalent drug conjugates with proteins that are formed at pH=10.2. The interaction between these antibiotics and serum proteins was explored in an attempt to develop improved diagnostic tests. There were considerable differences between the conjugates formed at physiological pH and those formed at pH=10.2, most notably a reduced number of conjugates were formed at physiological pH, and drugs interacted with multiple serum proteins. When the utility of the basophil activation test to detect penicillin or cephalosporin allergy was assessed using whole drugs instead of conjugates, they yielded high sensitivity (>80%) and specificity, and this test was also able to determine which other medications the patients would react to.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD(Pharmacy))--University of South Australia, 2019.
Provenance
Copyright 2019 Sherin Vareeckal-Joseph.
Description
1 ethesis (xxii, 290 pages) :
illustrations (some colour)
Includes bibliographical references (pages 266-290)
illustrations (some colour)
Includes bibliographical references (pages 266-290)
Access Status
506 0#$fstar $2Unrestricted online access