Biocompatible snowman-like tumor-targeting dimer nanoparticles for improved delivery efficiency and enhanced anti-tumor therapy

Simple item page
dc.contributor.authorYe, C.
dc.contributor.authorYan, X.
dc.contributor.authorDai, X.
dc.contributor.authorChen, R.
dc.contributor.authorLi, Q.
dc.contributor.authorXu, S.
dc.contributor.authorJiang, Q.
dc.contributor.authorYan, F.
dc.contributor.authorXu, S.
dc.contributor.authorZhao, C.X.
dc.contributor.authorZhao, P.
dc.contributor.authorChen, D.
dc.contributor.authorRuan, J.
dc.date.issued2023
dc.descriptionAvailable online 1 September 2023
dc.description.abstractChemotherapy is indispensable for the systematic treatment of aggressive malignancies, such as pancreatic ductal adenocarcinoma (PDAC), while delivery vehicles are essential for improving delivery efficiency and enhancing anti-tumor therapy. Here, we design and synthesize snowman-like tumor-targeting PLA/shellac-FA dimer nanoparticles (NPs), which demonstrate improved delivery efficiency and enhanced anti-tumor therapy. Paclitaxel (PTX) and curcumin (CUR) are co-loaded in PLA/shellac-FA dimer NPs and their delivery performance is optimized by tuning the particle shape to be snowman-like. In vivo tests confirm that PTX + CUR-loaded snowman-like PLA/shellac-FA dimer NPs could effectively reduce the proportion of tumor-associated macrophages (TAMs) in lymphocytes and reshape the M1/M2 polarization into an anti-tumor type. Meanwhile, the dimer NPs could enhance the infiltration of cytotoxic T lymphocytes (CTLs), thus activating the immune response in the tumor microenvironment (TME). The results suggest that snowman-like PLA/shellac-FA dimer NPs with a sharp shape can effectively improve the delivery efficiency and enhance the anti-tumor therapy, being a promising system for clinical applications.
dc.description.statementofresponsibilityChanqi Ye, Xiaoxiao Yan, Xiaomeng Dai, Ruyin Chen, Qiong Li, Shuaishuai Xu, Qi Jiang, Feifei Yan, Suzhen Xu, Chun-Xia Zhao, Peng Zhao, Dong Chen, Jian Ruan
dc.identifier.citationChemical Engineering Journal, 2023; 474:145766-1-145766-10
dc.identifier.doi10.1016/j.cej.2023.145766
dc.identifier.issn1385-8947
dc.identifier.issn1873-3212
dc.identifier.urihttps://hdl.handle.net/2440/140177
dc.language.isoen
dc.publisherElsevier BV
dc.relation.granthttp://purl.org/au-research/grants/arc/DP200101238
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2008698
dc.rights© 2023 Elsevier B.V. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.cej.2023.145766
dc.subjectDimer particle; Tumor-targeting; Sustained release; Anti-tumor therapy; Immune activation
dc.titleBiocompatible snowman-like tumor-targeting dimer nanoparticles for improved delivery efficiency and enhanced anti-tumor therapy
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Chemical Engineering publications