Association between dairy intake, lipids and vascular structure and function in diabetes
Date
2017
Authors
Petersen, K.S.
Keogh, J.B.
Lister, N.
Weir, J.M.
Meikle, P.J.
Clifton, P.M.
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Journal article
Citation
WORLD JOURNAL OF DIABETES, 2017; 8(5):202-212
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Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Jacquelyn M Weir, Peter J Meikle, Peter M Clifton
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Abstract
AIM to determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and function. METHODS A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes (n = 108). This paper comprises post-hoc analyses investigating the relationship between dairy intake, serum lipid species and vascular health. Central and peripheral blood pressure, carotid femoral pulse wave velocity, augmentation index, serum lipid species and dietary intake were measured at baseline and 3-mo. Common carotid artery intima media thickness was measured at baseline and 12-mo. RESULTS serum lipid species [lysophosphatidylcholine (LPC) 14:0, LPC 15:0, LPC 16:1, phosphatidylcholine (PC) 29:0 PC 30:0, PC 31:0 and cholesterol ester (CE) 14:0] were associated with the change in full fat dairy consumption (rho 0.19-0.25; p < 0.05). The 3-mo change in some lipids was positively associated with the 3-mo change in central systolic [LPC 14:0 (rho 0.30; p = 0.007), PC 30:0 (rho 0.28; p = 0.010)] and diastolic blood pressure [LPC 14:0 (rho 0.32; p = 0.004), LPC 15:0 (rho 0.23; p = 0.04), LPC 16:1 (rho 0.23; p = 0.035), PC 29:0 (rho 0.28; p = 0.01), PC 30:0 (rho 0.36; p = 0.001), PC 31:0 (rho 0.30; p = 0.007)] and 12-mo change in common carotid artery intimal medial thickness [CE 14:0 (rho 0.22; p = 0.02)]. Pulse wave velocity and augmentation index were unrelated to dairy and lipid species. CONCLUSION an increase in dairy associated lipids appears to be associated with an increase in blood pressure and common carotid intimal medial thickness.
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©The Author(s) 2017. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/