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Incorporation of FGF-2 into Pharmaceutical Grade Fucoidan/Chitosan Polyelectrolyte Multilayers

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dc.contributor.authorBenbow, N.L.
dc.contributor.authorKarpiniec, S.
dc.contributor.authorKrasowska, M.
dc.contributor.authorBeattie, D.A.
dc.date.issued2020
dc.descriptionData source: Supplementary material, https://www.mdpi.com/1660-3397/18/11/531/s1
dc.description.abstractBiopolymer polyelectrolyte multilayers are a commonly studied soft matter system for wound healing applications due to the biocompatibility and beneficial properties of naturally occurring polyelectrolytes. In this work, a popular biopolymer, chitosan, was combined with the lesser known polysaccharide, fucoidan, to create a multilayer film capable of sequestering growth factor for later release. Fucoidan has been shown to act as a heparin-mimic due to similarities in the structure of the two molecules, however, the binding of fibroblast growth factor-2 to fucoidan has not been demonstrated in a multilayer system. This study assesses the ability of fucoidan to bind fibroblast growth factor-2 within a fucoidan/chitosan polyelectrolyte multilayer structure using attenuated total internal reflectance infrared spectroscopy and quartz crystal microbalance with dissipation monitoring. The fibroblast growth factor-2 was sequestered into the polyelectrolyte multilayer as a cationic layer in the uppermost layers of the film structure. In addition, the diffusion of fibroblast growth factor-2 into the multilayer has been assessed.
dc.identifier.citationMarine Drugs, 2020; 18(11)
dc.identifier.doi10.3390/md18110531
dc.identifier.issn1660-3397
dc.identifier.issn1660-3397
dc.identifier.orcidKrasowska, M. [0000-0003-0309-1772]
dc.identifier.urihttps://hdl.handle.net/11541.2/145238
dc.language.isoen
dc.publisherMDPI
dc.relation.fundingAustralian Government Cooperative Research Centres Program
dc.relation.fundingARC FT100100393
dc.relation.granthttp://purl.org/au-research/grants/arc/FT100100393
dc.rightsCopyright 2020 The Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.3390/md18110531
dc.subjectBiopolymers
dc.subjectChitosan
dc.subjectPolysaccharides
dc.subjectFibroblast Growth Factor 2
dc.subjectSpectroscopy, Fourier Transform Infrared
dc.subjectPolyelectrolytes
dc.titleIncorporation of FGF-2 into Pharmaceutical Grade Fucoidan/Chitosan Polyelectrolyte Multilayers
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12207877370001831 13207877360001831 marinedrug.pdf
ror.mmsid9916460805101831

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