Current studentsExisting staffContact us
 

Steamed root of Rehmannia glutinosa Libosch. relieves methotrexate-induced intestinal mucositis in mice with manninotriose as a core mediator

Simple item page
dc.contributor.authorWei, L.
dc.contributor.authorSun, Y.
dc.contributor.authorLi, Y.
dc.contributor.authorXian, C.J.
dc.contributor.authorWen, X.S.
dc.date.issued2025
dc.description.abstractChemotherapy-induced intestinal mucositis is a serious complication with few effective treatment options. In Traditional Chinese Medicine (TCM), this toxicity is attributed to Qi and Yin deficiencies, and the steamed root of Rehmannia glutinosa Libosch. (SRR) is commonly prescribed for its therapeutic benefits. This study aimed to evaluate SRR's effects on methotrexate (MTX)-induced mucositis by modulating the gut microbiota. Mice were administered MTX (300 mg/kg) and SRR (1.56 g/kg), and gut microbiota changes were analysed by 16S rRNA sequencing. Network pharmacology was employed to identify SRR's active components. SRR alleviated MTXinduced fatigue, diarrhea, weight loss, and intestinal villous damage, and modulated gut microbiota by reducing Clostridium levels, adjusting the Firmicutes/Bacteroidetes ratio, and promoting Gram-positive bacteria. SRR also reduced oxidative damage and inflammation markers (MDA, iNOS and NF-kappa B) without affecting MTX blood levels. Manninotriose was identified as one of the key active constituents. In conclusion, SRR alleviates MTX-induced intestinal mucositis by exerting antioxidative, anti-inflammatory, and gut microbiota-modulating effects.
dc.identifier.citationCarbohydrate Polymer Technologies and Applications, 2025; 11(100919)
dc.identifier.doi10.1016/j.carpta.2025.100919
dc.identifier.issn2666-8939
dc.identifier.issn2666-8939
dc.identifier.orcidXian, C.J. [0000-0002-8467-2845]
dc.identifier.urihttps://hdl.handle.net/11541.2/44029
dc.language.isoen
dc.publisherELSEVIER
dc.relation.fundingNational Natural Science Foundation of China 81072984
dc.relation.fundingNational Natural Science Foundation of China 82200918
dc.relation.fundingNatural Science Foundation of Shandong Province Youth Fund ZR2021QC111
dc.relation.fundingChina-Australia Centre for Health Sciences Research
dc.rightsCopyright 2025 The Authors. (http://creativecommons.org/licenses/by-nc-nd/4.0/) Access Condition Notes: This is an open access article under the CC BY-NC-ND license
dc.source.urihttps://doi.org/10.1016/j.carpta.2025.100919
dc.subjectrehmannia glutinosa libosch.
dc.subjectmethotrexate-induced intestinal mucositis
dc.subjectclostridium
dc.subjectfirmicutes/bacteroidetes ratio
dc.subjectmanninotriose
dc.subjectproteobacteria and actinomycetes
dc.titleSteamed root of Rehmannia glutinosa Libosch. relieves methotrexate-induced intestinal mucositis in mice with manninotriose as a core mediator
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12305371350001831 13305371340001831 1-s2.0-S2666893925002609-main
ror.mmsid9917056267401831

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
1-s2.0-S2666893925002609-main.pdf
Size:
7.63 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections