Repetitive paired-pulse TMS increases motor cortex excitability and visuomotor skill acquisition in young and older adults

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dc.contributor.authorHand, B.J.
dc.contributor.authorMerkin, A.
dc.contributor.authorOpie, G.M.
dc.contributor.authorZiemann, U.
dc.contributor.authorSemmler, J.G.
dc.date.issued2023
dc.descriptionPublished: 08 September 2023
dc.description.abstractTranscranial magnetic stimulation (TMS) over primary motor cortex (M1) recruits indirect (I) waves that can be modulated by repetitive paired-pulse TMS (rppTMS). The purpose of this study was to examine the effect of rppTMS on M1 excitability and visuomotor skill acquisition in young and older adults. A total of 37 healthy adults (22 young, 18-32 yr; 15 older, 60-79 yr) participated in a study that involved rppTMS at early (1.4 ms) and late (4.5 ms) interstimulus intervals (ISIs), followed by the performance of a visuomotor training task. M1 excitability was examined with motor-evoked potential (MEP) amplitudes and short-interval intracortical facilitation (SICF) using posterior-anterior (PA) and anterior-posterior (AP) TMS current directions. We found that rppTMS increased M1 excitability in young and old adults, with the greatest effects for PA TMS at the late ISI (4.5 ms). Motor skill acquisition was improved by rppTMS at an early (1.4 ms) but not late (4.5 ms) ISI in young and older adults. An additional study using a non-I-wave interval (3.5 ms) also showed increased M1 excitability and visuomotor skill acquisition. These findings show that rppTMS at both I-wave and non-I-wave intervals can alter M1 excitability and improve visuomotor skill acquisition in young and older adults.
dc.description.statementofresponsibilityBrodie J. Hand, Ashley Merkin, George M. Opie, Ulf Ziemann, John G. Semmler
dc.identifier.citationCerebral Cortex, 2023; 33(20):10660-10675
dc.identifier.doi10.1093/cercor/bhad315
dc.identifier.issn1047-3211
dc.identifier.issn1460-2199
dc.identifier.orcidHand, B.J. [0000-0002-9778-343X]
dc.identifier.orcidOpie, G.M. [0000-0001-7771-7569]
dc.identifier.orcidSemmler, J.G. [0000-0003-0260-8047]
dc.identifier.urihttps://hdl.handle.net/2440/139438
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.relation.granthttp://purl.org/au-research/grants/arc/DP200101009
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1139723
dc.rights© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
dc.source.urihttps://doi.org/10.1093/cercor/bhad315
dc.subjectTranscranial magnetic stimulation
dc.subjectAging
dc.subjectPlasticity
dc.subjectSkill acquisition
dc.titleRepetitive paired-pulse TMS increases motor cortex excitability and visuomotor skill acquisition in young and older adults
dc.typeJournal article
pubs.publication-statusPublished

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