A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

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dc.contributor.authorMellor, J.
dc.contributor.authorBrown, M.
dc.contributor.authorIrving, H.
dc.contributor.authorZalcberg, J.
dc.contributor.authorDobrovic, A.
dc.date.issued2013
dc.description.abstractAntibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic mAbs has been reported to correlate with specific polymorphisms in two of these genes: FCGR2A (H131R) and FCGR3A (V158F). These polymorphisms are associated with differential affinity of the receptors for mAbs. This review critically examines the current evidence for genotyping the corresponding single nucleotide polymorphisms (SNPs) to predict response to mAbs in patients with cancer.
dc.description.statementofresponsibilityJames D Mellor, Michael P Brown, Helen R Irving, John R Zalcberg and Alexander Dobrovic
dc.identifier.citationJournal of Hematology and Oncology, 2013; 6(1):1-10
dc.identifier.doi10.1186/1756-8722-6-1
dc.identifier.issn1756-8722
dc.identifier.issn1756-8722
dc.identifier.orcidBrown, M. [0000-0002-5796-1932] [0000-0002-6678-1407]
dc.identifier.urihttp://hdl.handle.net/2440/85793
dc.language.isoen
dc.publisherBioMed Central
dc.rights© 2013 Mellor et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1186/1756-8722-6-1
dc.subjectFCGR2A; FCGR3A; trastuzumab; rituximab; cetuximab; ADCC
dc.titleA critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
dc.typeJournal article
pubs.publication-statusPublished

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