Premixed, injectable PLA-modified calcium deficient apatite biocement(cd-AB)with washout resistance

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dc.contributor.authorWu, F.
dc.contributor.authorNgothai, Y.
dc.contributor.authorWei, J.
dc.contributor.authorLiu, C.
dc.contributor.authorO'Neill, B.
dc.contributor.authorWu, Y.
dc.date.issued2012
dc.description.abstractBy using a non-aqueous solution as the mixing liquid, the washout resistance of the calcium deficient apatite biocement (cd-AB) was significantly improved, over that of the conventional method of using cd-AB with water as the liquid phase. In this study, premixed and injectable cd-AB was prepared, which had the advantage of being stable in the syringe and hardens only after being delivered to the defect area. The cd-AB powder with a Ca/P ratio of 1.5 consists of a mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA). A solution of polylactide (PLA) in N-methyl-2-pyrrolidone (NMP) was used as the liquid phase of the premixed cd-AB. The premixed cd-AB paste injected into an aqueous environment exhibited excellent washout resistance. The premixed cd-AB had longer setting time and lower compressive strength than conventional cd-AB. The hydration products of premixed cd-AB were a mixture of calcium deficient hydroxyapatite (cd-HA) and PLA. In vitro Tris-HCl immersion tests demonstrated that the premixed cd-AB could be degradable. The results revealed that the premixed cd-AB was cytocompatible and had no adverse effects on the attachment and proliferation of MG-63 osteoblast-like cells in vitro. The most distinct advantages of premixed and injectable PLA-modified cd-AB were its excellent washout resistance and in vitro degradability, suggesting that it may be a promising candidate for bone repair.
dc.description.statementofresponsibilityFan Wu, Yung Ngothai, Jie Wei, Changsheng Liu, Brian O’Neill and Yuequn Wu
dc.identifier.citationColloids and Surfaces B: Biointerfaces, 2012; 92:113-120
dc.identifier.doi10.1016/j.colsurfb.2011.11.037
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.orcidNgothai, Y. [0000-0002-0199-4225]
dc.identifier.urihttp://hdl.handle.net/2440/72057
dc.language.isoen
dc.publisherElsevier Science BV
dc.rights© 2011 Elsevier B.V. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.colsurfb.2011.11.037
dc.subjectCell Line
dc.subjectOsteoblasts
dc.subjectHumans
dc.subjectApatites
dc.subjectCalcium
dc.subjectBone Cements
dc.subjectPolyesters
dc.subjectMicroscopy, Electron, Scanning
dc.subjectX-Ray Diffraction
dc.subjectInjections
dc.subjectMaterials Testing
dc.subjectCompressive Strength
dc.subjectHardness
dc.subjectTime Factors
dc.titlePremixed, injectable PLA-modified calcium deficient apatite biocement(cd-AB)with washout resistance
dc.typeJournal article
pubs.publication-statusPublished

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