Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction

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dc.contributor.authorLinz, D.
dc.contributor.authorHohl, M.
dc.contributor.authorVollmar, J.
dc.contributor.authorUkena, C.
dc.contributor.authorMahfoud, F.
dc.contributor.authorBöhm, M.
dc.date.issued2017
dc.description.abstractAtrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Multiple conditions like hypertension, heart failure, diabetes, sleep apnoea, and obesity play a role for the initiation and perpetuation of AF. Recently, a potential association between gastroesophageal reflux disease (GERD) and AF development has been proposed due to the close anatomic vicinity of the oesophagus and the left atrium. As an understanding of the association between acid reflux disease and AF may be important in the global multimodal treatment strategy to further improve outcomes in a subset of patients with AF, we discuss potential atrial arrhythmogenic mechanisms in patients with GERD, such as gastric and subsequent systemic inflammation, impaired autonomic stimulation, mechanical irritation due to anatomical proximity of the left atrium and the oesophagus, as well as common comorbidities like obesity and sleep-disordered breathing. Data on GERD and oesophageal lesions after AF-ablation procedures will be reviewed. Treatment of GERD to avoid AF or to reduce AF burden might represent a future treatment perspective but needs to be scrutinized in prospective trials.
dc.description.statementofresponsibilityDominik Linz, Mathias Hohl, Johanna Vollmar, Christian Ukena, Felix Mahfoud and Michael Bőhm
dc.identifier.citationEuropace, 2017; 19(1):16-20
dc.identifier.doi10.1093/europace/euw092
dc.identifier.issn1099-5129
dc.identifier.issn1532-2092
dc.identifier.orcidLinz, D. [0000-0003-4893-0824]
dc.identifier.urihttp://hdl.handle.net/2440/117113
dc.language.isoen
dc.publisherOxford Unversity Press
dc.rightsPublished on behalf of the European Society of Cardiology. All rights reserved. & The Author 2016.
dc.source.urihttps://doi.org/10.1093/europace/euw092
dc.subjectAtrial fibrillation; gastroesophageal reflux; autonomic nervous system; pulmonary vein isolation
dc.titleAtrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction
dc.typeJournal article
pubs.publication-statusPublished

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