Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae

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dc.contributor.authorBriles, D.
dc.contributor.authorHollingshead, S.
dc.contributor.authorPaton, J.
dc.contributor.authorAdes, E.
dc.contributor.authorNovak, L.
dc.contributor.authorvan Ginkel, F.
dc.contributor.authorBenjamin Jr, W.
dc.date.issued2003
dc.description.abstractIntranasal infection of mice with certain strains of capsular group 19 Streptococcus pneumoniae can result in focal pneumonia in the absence of bacteremia. Using this model of murine pneumonia, we demonstrated that immunization with recombinant forms of either pneumococcal surface protein A (PspA) or PdB (a genetically detoxified derivative of pneumolysin) elicited significant protection against focal pulmonary infection. This may be the first demonstration that a proposed vaccine antigen can protect against pneumococcal pneumonia. The best protection was obtained by immunizing mice with a mixture of PspA and PdB, indicating that the protection elicited by these antigens can complement each other. This result is in agreement with previous studies that used pneumococcal sepsis and nasal colonization models and demonstrate that the best protein vaccines for prevention of infection may be those that include more than one protection-eliciting pneumococcal protein.
dc.description.statementofresponsibilityDavid E. Briles, Susan K. Hollingshead, James C. Paton, Edwin W. Ades, Lea Novak, Frederik W. van Ginkel, and William H. Benjamin, Jr.
dc.identifier.citationJournal of Infectious Diseases, 2003; 188(3):339-348
dc.identifier.doi10.1086/376571
dc.identifier.issn0022-1899
dc.identifier.issn1537-6613
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]
dc.identifier.urihttp://hdl.handle.net/2440/3051
dc.language.isoen
dc.publisherUniv Chicago Press
dc.rights© 2003 by the Infectious Diseases Society of America. All rights reserved.
dc.source.urihttps://doi.org/10.1086/376571
dc.subjectLung
dc.subjectAnimals
dc.subjectMice, Inbred CBA
dc.subjectMice
dc.subjectStreptococcus pneumoniae
dc.subjectPneumonia, Pneumococcal
dc.subjectFocal Infection
dc.subjectDisease Models, Animal
dc.subjectBacterial Proteins
dc.subjectRecombinant Proteins
dc.subjectVaccines, Synthetic
dc.subjectStreptolysins
dc.subjectPneumococcal Vaccines
dc.subjectVaccines, Combined
dc.subjectAntigens, Bacterial
dc.subjectImmunization
dc.subjectAdministration, Intranasal
dc.subjectFemale
dc.titleImmunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae
dc.typeJournal article
pubs.publication-statusPublished

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