Polymer−lipid hybrid microparticles enhance the intracellular uptake and activity of rifampicin against bacterially infected macrophages /
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(Published version)
Date
2020
Authors
Maghrebi, Sajedeh
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
thesis
Citation
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Conference Name
Abstract
This thesis has addressed the urgent need for the development of effective carrier systems that systematically enhance the cellular uptake and localization of antibiotic drugs for the treatment of intracellular pathogens. The designs, fabrication and characterization of novel polymer-lipid hybrid systems and their application to target intracellular bacteria located in macrophages are described. Both biocompatible and biodegradable polymers were used to create hybridized, solid-state, lipid-based drug delivery systems that combine the advantages of lipid and polymeric nanoparticles, while minimizing their individual physicochemical and biological limitations. The engineered hybrid systems significantly enhanced antibiotic delivery to macrophages and showed efficacious treatment of challenging intracellular infections.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences
School of Pharmacy and Medical Sciences
Dissertation Note
Thesis (PhD(Pharmaceutical Science))--University of South Australia, 2020.
Provenance
Copyright 2020 Sajedeh Maghrebi.
Description
1 ethesis (xv, 129 pages) :
illustrations (chiefly colour), charts (chiefly colour)
Includes bibliographical references (pages 114-124)
illustrations (chiefly colour), charts (chiefly colour)
Includes bibliographical references (pages 114-124)
Access Status
506 0#$fstar $2Unrestricted online access