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Safety and efficacy of progressive resistance training in breast cancer: a systematic review and meta-analysis

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dc.contributor.authorCheema, B.
dc.contributor.authorKilbreath, S.
dc.contributor.authorFahey, P.
dc.contributor.authorDelaney, G.
dc.contributor.authorAtlantis, E.
dc.date.issued2014
dc.descriptionThe online version of this article (doi:10.​1007/​s10549-014-3162-9) contains supplementary material, which is available to authorized users.
dc.description.abstractThe purpose of this study was to assess the safety and efficacy of progressive resistance training (PRT) in breast cancer. Randomized controlled trials (RCTs) published to November 2013 that reported on the effects of PRT (>6 weeks) on breast cancer-related lymphedema (BCRL) (incidence/exacerbation, arm volume, and symptom severity), physical functioning (upper and lower body muscular strength), and health-related quality of life (HRQoL) in breast cancer patients were included. Of 446 citations retrieved, 15 RCTs in 1,652 patients were included and yielded five studies on BCRL incidence/exacerbation (N = 647), four studies on arm volume (N = 384) and BCRL symptom severity (N = 479), 11 studies on upper body muscular strength (N = 1,252), nine studies on lower body muscular strength (N = 1,079), and seven studies on HRQoL (N = 823). PRT reduced the risk of BCRL versus control conditions [OR = 0.53 (95% CI 0.31-0.90); I2 = 0%] and did not worsen arm volume or symptom severity (both SMD = -0.07). PRT significantly improved upper [SMD = 0.57 (95% CI 0.37-0.76); I2 = 58.4%] and lower body muscular strength [SMD = 0.48 (95% CI 0.30-0.67); I2 = 46.7%] but not HRQoL [SMD = 0.17 (95% CI -0.03 to 0.38); I2 = 47.0%]. The effect of PRT on HRQoL became significant in our sensitivity analysis when two studies conducted during adjuvant chemotherapy [SMD = 0.30 (95% CI 0.04-0.55), I2 = 37.0%] were excluded. These data indicate that PRT improves physical functioning and reduces the risk of BCRL. Clinical practice guidelines should be updated to inform clinicians on the benefits of PRT in this cohort.
dc.description.statementofresponsibilityBirinder S. Cheema, Sharon L. Kilbreath, Paul P. Fahey, Geoffrey P. Delaney, Evan Atlantis
dc.identifier.citationBreast Cancer Research and Treatment, 2014; 148(2):249-268
dc.identifier.doi10.1007/s10549-014-3162-9
dc.identifier.issn0167-6806
dc.identifier.issn1573-7217
dc.identifier.orcidAtlantis, E. [0000-0001-5877-6141]
dc.identifier.urihttp://hdl.handle.net/2440/90894
dc.language.isoen
dc.publisherSpringer US
dc.rights© Springer Science+Business Media New York 2014
dc.source.urihttps://doi.org/10.1007/s10549-014-3162-9
dc.subjectStrength; Physical functioning; Quality of life; Rehabilitation; Exercise; Health; Lymphedema; Survival; Fitness
dc.titleSafety and efficacy of progressive resistance training in breast cancer: a systematic review and meta-analysis
dc.typeJournal article
pubs.publication-statusPublished

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