Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa
Date
2011
Authors
Zeng, X.
Liu, X.
Bian, J.
Pei, G.
Dai, H.
Polyak, S.
Song, F.
Ma, L.
Wang, Y.
Zhang, L.
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Journal article
Citation
Antimicrobial Agents and Chemotherapy, 2011; 55(6):3015-3017
Statement of Responsibility
Xiangping Zeng, Xiangyang Liu, Jiang Bian, Gang Pei, Huanqin Dai, Steven W. Polyak, Fuhang Song, Li Ma, Yuqiang Wang, and Lixin Zhang
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Abstract
Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa.
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Copyright © 2011, American Society for Microbiology. All Rights Reserved.