The interaction between the maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth

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dc.contributor.authorAndraweera, P.
dc.contributor.authorDekker, G.
dc.contributor.authorThompson, S.
dc.contributor.authorNorth, R.
dc.contributor.authorMcCowan, L.
dc.contributor.authorRoberts, C.
dc.date.issued2012
dc.description.abstractObesity is associated with an increased level of inflammation. Interactions between inflammatory and angiogenic pathways are implicated in the major pregnancy disorders. The aim of this study was to investigate whether functional polymorphisms in angiogenesis-regulating genes (VEGFA rs699947, VEGFA rs3025039, KDR rs2071559 and ANGPT1 rs2507800) interact with the maternal BMI to modify the risk of a spontaneous preterm birth (sPTB). We conducted a nested case–control study of 1190 nulliparous Caucasian women (107 sPTBs and 1083 controls). Spontaneous PTB was defined as spontaneous preterm labour or a preterm premature rupture of membranes resulting in a preterm birth at <37 weeks of gestation. DNA was extracted from the peripheral blood and genotyped using the Sequenom MassARRAY system. Among overweight or obese women (BMI ≥25), the VEGFA rs699947 AA genotype was associated with a higher risk of sPTBs [odds ratio (OR) = 2.4, 95% confidence interval (CI): 1.4–4.6, P = 0.001] and a significant interaction between the BMI and the polymorphism was detected (OR = 4.2, 95% CI: 1.7–10.9, P = 0.003). Among women with a BMI < 25, ANGPT1 rs2507800 AA genotype was associated with a higher risk of sPTB (OR = 2.3, 95% CI: 1.2–4.4, P = 0.02) and a significant interaction between BMI and the polymorphism was detected (OR = 3.3, 95% CI: 1.1–9.3, P = 0.02). All results remained significant after adjusting for potential confounding factors. The maternal BMI interacts with angiogenesis-regulating gene polymorphisms to modify the risk of sPTBs. Trial Registry Name: Screening nulliparous women to identify the combinations of clinical risk factors and/or biomarkers required to predict pre-eclampsia, small-for-gestational-age babies and spontaneous preterm birth (https://www.anzctr.org.au). Registration number: ACTRN12607000551493.
dc.description.statementofresponsibilityPrabha H. Andraweera, Gustaaf A. Dekker, Steven D. Thompson, Robyn A. North, Lesley M.E. McCowan and Claire T. Roberts on behalf of the SCOPE Consortium
dc.identifier.citationMolecular Human Reproduction, 2012; 18(9):459-465
dc.identifier.doi10.1093/molehr/gas016
dc.identifier.issn1360-9947
dc.identifier.issn1460-2407
dc.identifier.orcidAndraweera, P. [0000-0003-2434-8370]
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]
dc.identifier.urihttp://hdl.handle.net/2440/73773
dc.language.isoen
dc.publisherOxford Univ Press
dc.rights© The Author 2012.
dc.source.urihttps://doi.org/10.1093/molehr/gas016
dc.subjectSCOPE Consortium
dc.subjectHumans
dc.subjectPregnancy Complications
dc.subjectPremature Birth
dc.subjectObesity
dc.subjectInflammation
dc.subjectVascular Endothelial Growth Factor Receptor-2
dc.subjectAngiopoietin-1
dc.subjectVascular Endothelial Growth Factor A
dc.subjectBody Mass Index
dc.subjectOdds Ratio
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectPregnancy
dc.subjectNeovascularization, Physiologic
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdult
dc.subjectFemale
dc.titleThe interaction between the maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth
dc.typeJournal article
pubs.publication-statusPublished

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