Asymptomatic elevation of creatine kinase in patients with hyponatremia
| dc.contributor.author | Khow, K. | |
| dc.contributor.author | Lau, S. | |
| dc.contributor.author | Li, J. | |
| dc.contributor.author | Yong, T. | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Elevated creatine kinase (hyper-CKemia) has been observed in small number of patients with hyponatremia. This study evaluated the features and outcomes of patients admitted with hyponatremia complicated by hyper-CKemia. Patients admitted with hyponatremia and concurrently found to have elevated creatine kinase (CK) of above 375 IU/L (male) or 225 IU/L (female), over a 5-year period were retrospectively reviewed. Those with myocardial injury (elevated CK-MB isoenzyme [CK-MB/CK percentage of >2.5%] or Troponin T [>0.02 μg/L]), traumatic or ischemic muscle damage, primary myopathic disorder, seizures prior to CK measurement or those taking medications which can cause myopathy, were excluded. Thirty-two patients with hyponatremia and hyper-CKemia were identified. All patients had no muscular symptoms or weakness. The commonest cause of hyponatremia in this cohort was related to diuretics (50%). The mean sodium level on presentation was 116.0 ± 6.9 mmol/L and the median peak CK was 895.5 (interquartile range: 610.8-1691.8) IU/L. Six (18%) patients developed acute kidney injury (AKI). The length of hospital admission of the entire cohort was 8.0 ± 5.8 days. Patients with hyper-CKemia in the setting of diuretic-associated hyponatremia were older and had longer hospital length of stay compared with primary-polydipsia-associated. Asymptomatic hyper-CKemia is an uncommon association with hyponatremia of various etiologies. Hyponatremia-associated hyper-CKemia can be complicated by AKI. | |
| dc.description.statementofresponsibility | Kareeann S. F. Khow, Su Y. Lau, Jordan Y. Z. Li and Tuck Y. Yong | |
| dc.identifier.citation | Renal Failure, 2014; 36(6):908-911 | |
| dc.identifier.doi | 10.3109/0886022X.2014.900600 | |
| dc.identifier.issn | 0886-022X | |
| dc.identifier.issn | 1525-6049 | |
| dc.identifier.orcid | Khow, K. [0000-0003-3960-1025] | |
| dc.identifier.uri | http://hdl.handle.net/2440/115680 | |
| dc.language.iso | en | |
| dc.publisher | Taylor & Francis | |
| dc.rights | © 2014 Informa Healthcare USA, Inc. | |
| dc.source.uri | https://doi.org/10.3109/0886022x.2014.900600 | |
| dc.subject | Creatine kinase; diuretic; hyper-CKemia; hyponatremia; polydipsia | |
| dc.title | Asymptomatic elevation of creatine kinase in patients with hyponatremia | |
| dc.type | Journal article | |
| pubs.publication-status | Published |