Silver absorption on burns after application of Acticoat™: data from pediatric patients and a porcine burn model

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dc.contributor.authorWang, X.
dc.contributor.authorKempf, M.
dc.contributor.authorMott, J.
dc.contributor.authorChang, H.
dc.contributor.authorFrancis, R.
dc.contributor.authorLiu, P.
dc.contributor.authorCuttle, L.
dc.contributor.authorOlszowy, H.
dc.contributor.authorKravchuk, O.
dc.contributor.authorMill, J.
dc.contributor.authorKimble, R.
dc.date.issued2009
dc.description.abstractSilver dressings have been widely used to successfully prevent burn wound infection and sepsis. However, a few case studies have reported the functional abnormality and failure of vital organs, possibly caused by silver deposits. The aim of this study was to investigate the serum silver level in the pediatric burn population and also in several internal organs in a porcine burn model after the application of Acticoat. A total of 125 blood samples were collected from 46 pediatric burn patients. Thirty-six patients with a mean of 13.4% TBSA burns had a mean peak serum silver level of 114 microg/L, whereas 10 patients with a mean of 1.85% TBSA burns had an undetectable level of silver (<5.4 microg/L). Overall, serum silver levels were closely related to burn sizes. However, the highest serum silver was 735 microg/L in a 15-month-old toddler with 10% TBSA burns and the second highest was 367 microg/L in a 3-year old with 28% TBSA burns. In a porcine model with 2% TBSA burns, the mean peak silver level was 38 microg/L at 2 to 3 weeks after application of Acticoat and was then significantly reduced to an almost undetectable level at 6 weeks. Of a total of four pigs, silver was detected in all four livers (1.413 microg/g) and all four hearts (0.342 microg/g), three of four kidneys (1.113 microg/g), and two of four brains (0.402 microg/g). This result demonstrated that although variable, the level of serum silver was positively associated with the size of burns, and significant amounts of silver were deposited in internal organs in pigs with only 2% TBSA burns, after application of Acticoat.
dc.description.statementofresponsibilityXue-Qing Wang, Margit Kempf, Jonathon Mott, Hong-En Chang, Rod Francis, Pei-Yun Liu, Leila Cuttle, Henry Olszowy, Olena Kravchuk, Julie Mill, Roy M. Kimble
dc.identifier.citationJournal of Burn Care and Research, 2009; 30(2):341-349
dc.identifier.doi10.1097/BCR.0b013e318198a64c
dc.identifier.issn1559-047X
dc.identifier.issn1559-0488
dc.identifier.orcidKravchuk, O. [0000-0001-5291-3600]
dc.identifier.urihttp://hdl.handle.net/2440/70213
dc.language.isoen
dc.publisherMosby Inc
dc.rightsCopyright: © 2009 The American Burn Association
dc.source.urihttps://doi.org/10.1097/bcr.0b013e318198a64c
dc.subjectAnimals
dc.subjectSwine
dc.subjectHumans
dc.subjectBurns
dc.subjectSilver
dc.subjectPolyethylenes
dc.subjectPolyesters
dc.subjectAdministration, Topical
dc.subjectAnalysis of Variance
dc.subjectLinear Models
dc.subjectBandages
dc.subjectAbsorption
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectFemale
dc.subjectMale
dc.titleSilver absorption on burns after application of Acticoat™: data from pediatric patients and a porcine burn model
dc.title.alternativeSilver absorption on burns after application of Acticoat(TM): data from pediatric patients and a porcine burn model
dc.typeJournal article
pubs.publication-statusPublished

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