Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology
Date
2018
Authors
Lidgerwood, G.E.
Pitson, S.M.
Bonder, C.
Pébay, A.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Progress in Lipid Research, 2018; 72:42-54
Statement of Responsibility
Grace E. Lidgerwood, Stuart M. Pitson, Claudine Bonder, Alice Pébay
Conference Name
Abstract
Stem cells are unique in their ability to self-renew and differentiate into various cell types. Because of these features, stem cells are key to the formation of organisms and play fundamental roles in tissue regeneration and repair. Mechanisms controlling their fate are thus fundamental to the development and homeostasis of tissues and organs. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive phospholipids that play a wide range of roles in multiple cell types, during developmental and pathophysiological events. Considerable evidence now demonstrates the potent roles of LPA and S1P in the biology of pluripotent and adult stem cells, from maintenance to repair. Here we review their roles for each main category of stem cells and explore how those effects impact development and physiopathology.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© 2018 Elsevier Ltd. All rights reserved.