Integrating novel neuropathological markers into longitudinal population-based dementia studies
Date
2013
Authors
Keage, H.A.D.
Hunter, S.
Brayne, C.
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Journal article
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Australasian Epidemiologist, 2013; 20(1):13-14
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Abstract
Assessing novel neuropathological markers in longitudinal clinicopathological studies of dementia is difficult, with tissue sometimes collected over decades. We discuss why it is essential for such studies to assess novel dementia-related neuropathologies and the methodological issues involved. Longitudinal studies are less prone to bias than other study designs and provide unique information about the course of disease. However, changing tissue storage conditions over time may affect results and because the avoidance of tissue wastage is paramount, consensus guidelines are urgently required to guide best staining practices. The replication of an association between a neuropathological marker and clinical dementia in a population-based study is essential for the understanding of dementia biology to progress.
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Copyright 2013 Australasian Epidemiological Association