Amphibian peptides : their structures and bioactivity / by Kate Louise Wegener.
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Date
2001
Authors
Wegener, Kate Louise
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Abstract
The skin secretion of the northern Australian frog Litoria dahlii was investigated, with eleven novel peptides identified. These peptides have moderate biological activity, including antibacterial and anticancer actions, as well as the capacity to inhibit the enzyme neuronal nitric oxide synthase. Many potent broad-spectrum antibiotics have been isolated from Australian amphibians, and are believed to act by disrupting the bacterial cell membrane by forming transmembrane 'barrel-stave' type ion channels, lipid-incorporating toroidal pores or by assembling as a 'carpet' over the mebrane surface. The structures of several antibacterial peptides were determined using nuclear magnetic resonance spectroscopy and restrained molecular dynamics calculations. Experimental results suggest these peptides operate by the 'carpet' mechanism.
School/Discipline
Dept. of Chemistry
Dissertation Note
Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2002
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This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals. Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text.
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Copies of author's previously published works inserted.
Bibliography: leaves 237-268.
x, 275, [43] leaves : ill. (chiefly col.) ; 30 cm.
Bibliography: leaves 237-268.
x, 275, [43] leaves : ill. (chiefly col.) ; 30 cm.