Current studentsExisting staffContact us
 

Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery

Simple item page
dc.contributor.authorAbdella, S.
dc.contributor.authorKim, S.
dc.contributor.authorAfinjuomo, F.
dc.contributor.authorSong, Y.
dc.contributor.authorUpton, R.
dc.contributor.authorGarg, S.
dc.date.issued2024
dc.description.abstractCannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and low oral bioavailability. To overcome the challenges associated with CBD delivery, we employed Design of Experiments (DoE), lipid carriers, and 3D printing techniques to optimize and develop buccal film loaded with CBD-NLCs. Three-factor Box-Behnken Design was carried out to optimise the NLCs and analyse the effect of independent factors on dependent factors. The emulsification-ultrasonication technique was used to prepare the NLCs. A pressure-assisted micro-syringe printing technique was used to produce the films. The produced films were studied for physicochemical, and mechanical properties, release profiles, and predicted in vivo performance. The observed particle size of the NLCs ranged from 12.17 to 84.91 nm whereas the PDI varied from 0.099 to 0.298. Lipid and sonication time positively affected the particle size whereas the surfactant concentration was inversely related. CBD was incorporated into the optimal formulation and the observed particle size, PDI, and zeta potential for the CBD-NLCs were 94.2 ± 0.47 nm, 0.11 ± 0.01 and - 11.8 ± 0.52 mV. Hydroxyethyl cellulose (HEC)-based gel containing the CBD-NLCs was prepared and used as a feed for 3D printing. The CBD-NLCs film demonstrated a slow and sustained in vitro release profile (84. 11 ± 7.02% in 6 h). The predicted AUC<sub>0-10</sub> h, C<sub>max</sub>, and T<sub>max</sub> were 201.5 µg·h/L, 0.74 µg/L, and 1.28 h for a film with 0.4 mg of CBD, respectively. The finding demonstrates that a buccal film of CBD-NLCs can be fabricated using 3D printing.
dc.identifier.citationDrug Delivery and Translational Research, 2024; 14(4):984-1004
dc.identifier.doi10.1007/s13346-023-01446-0
dc.identifier.issn2190-393X
dc.identifier.issn2190-3948
dc.identifier.orcidUpton, R. [0000-0001-9996-4886]
dc.identifier.orcidGarg, S. [0000-0001-7253-2629]
dc.identifier.urihttps://hdl.handle.net/11541.2/36712
dc.language.isoen
dc.publisherSPRINGER HEIDELBERG
dc.rightsCopyright 2023 The author(s). Published by Springer. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1007/s13346-023-01446-0
dc.subjectCannabidiol
dc.subjectLipids
dc.subjectDrug Carriers
dc.subjectParticle Size
dc.subjectNanostructures
dc.titleCombining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12283498630001831 13283508680001831 Open Access Published Version
ror.mmsid9916803426401831

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
9916803426401831_12283498630001831_s13346-023-01446-0.pdf
Size:
2.84 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections