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Hydrothermally etched titanium: a review on a promising mechano-bactericidal surface for implant applications

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dc.contributor.authorHayles, A.
dc.contributor.authorHasan, J.
dc.contributor.authorBright, R.
dc.contributor.authorPalms, D.
dc.contributor.authorBrown, T.
dc.contributor.authorBarker, D.
dc.contributor.authorVasilev, K.
dc.date.issued2021
dc.description.abstractThe growing demand for titanium-based implants and the subsequent rise in implant-associated infections necessitate novel developments in anti-infective technologies. Recent research has drawn inspiration from nature to solve this problem. The nanoscale topography observed on cicada and dragonfly wings serves as a blueprint for synthetic analogs which seek to kill bacteria on contact through mechanical forces. This type of interaction has been dubbed the mechano-bactericidal effect. Various techniques have been utilized to mimic and improve upon these natural bactericidal surfaces. Alkaline hydrothermal etching is a simple and cost-effective technique to fabricate nanoscale protrusions on titanium and its alloys. This review aims to consolidate the current knowledge surrounding how fabrication parameters lead to varying surface topographies on titanium substrates, and subsequently, how surface topography and bacterial characteristics affect bactericidal activity. The bactericidal mechanism of hydrothermally etched titanium is inferred from comparisons with similar mechano-bactericidal biomaterials. The hostility of hydrothermally etched titanium toward bacteria is discussed in contrast to the observed host cell compatibility. Last, suggestions are made for the standardization of terminology in this emerging field.
dc.identifier.citationMaterials Today Chemistry, 2021; 22(100622):1-11
dc.identifier.doi10.1016/j.mtchem.2021.100622
dc.identifier.issn2468-5194
dc.identifier.issn2468-5194
dc.identifier.urihttps://hdl.handle.net/11541.2/27573
dc.language.isoen
dc.publisherElsevier
dc.relation.fundingUniversity of South Australia
dc.relation.fundingARC DP180101254
dc.relation.fundingNHMRC 1194466
dc.relation.fundingDepartment of Industry, Science, Energy and Resources (Innovative Manufacturing CRC Ltd) Global Orthopaedic Technology Pty Ltd IMCRC/GOT/13032018
dc.relation.fundingCorin Australia
dc.rightsCopyright 2021 Elsevier
dc.source.urihttps://doi.org/10.1016/j.mtchem.2021.100622
dc.subjectbiomaterial
dc.subjectbiomimetic
dc.subjectfabrication
dc.subjectmechanism
dc.subjectnanopillar
dc.subjectnanostructured
dc.titleHydrothermally etched titanium: a review on a promising mechano-bactericidal surface for implant applications
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916602249601831

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