Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation
Date
2016
Authors
Gong, P.
Es'haghian, S.
Harms, K.
Murray, A.
Rea, S.
Kennedy, B.
Wood, F.
Sampson, D.
McLaughlin, R.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Biophotonics, 2016; 9(6):626-636
Statement of Responsibility
Peijun Gong, Shaghayegh Es'haghian, Karl-Anton Harms, Alexandra Murray, Suzanne Rea, Brendan F. Kennedy, Fiona M. Wood, David D. Sampson, and Robert A. McLaughlin
Conference Name
Abstract
This study presents the first in vivo longitudinal assessment of scar vasculature in ablative fractional laser treatment using optical coherence tomography (OCT). A method based on OCT speckle decorrelation was developed to visualize and quantify the scar vasculature over the treatment period. Through reliable co-location of the imaging field of view across multiple imaging sessions, and compensation for motion artifact, the study was able to track the same scar tissue over a period of several months, and quantify changes in the vasculature area density. The results show incidences of occlusion of individual vessels 3 days after the first treatment. The subsequent responses ˜20 weeks after the initial treatment show differences between immature and mature scars. Image analysis showed a distinct decrease (25 ± 13%, mean ± standard deviation) and increase (19 ± 5%) of vasculature area density for the immature and mature scars, respectively. This study establishes the feasibility of OCT imaging for quantitative longitudinal monitoring of vasculature in scar treatment. En face optical coherence tomography vasculature images pre-treatment (top) and ˜20 weeks after the first laser treatment (bottom) of a mature burn scar. Arrows mark the same vessel pattern.
School/Discipline
Dissertation Note
Provenance
Description
Published online 12 August 2015
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© 2015 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim