Current studentsExisting staffContact us
 

Calcitonin receptors, bone sialoprotein and osteopontin are expressed in primary breast cancers

Simple item page
dc.contributor.authorGillespie, M.
dc.contributor.authorThomas, R.
dc.contributor.authorPu, Z.Y.
dc.contributor.authorZhou, H.
dc.contributor.authorFindlay, D.
dc.date.issued1997
dc.description.abstractSeveral human breast cancer cell lines express the calcitonin receptor (CTR), but this has not been demonstrated previously in clinical breast cancers. We examined 18 primary breast cancers by reverse transcription-PCR, for expression of CTR and of the bone proteins osteopontin (OPN) and bone sialoprotein (BSP). OPN and CTR were expressed by each of the tumours, and 7 (39%) additionally expressed an alternate form of CTR, whilst BSP was expressed by 13 tumours (72%). In situ hybridisation confirmed that expression of OPN and CTR was confined to the tumour cells. Expression of CTR, BSP and OPN may prove to be a useful marker for breast cancers, and their role in the homing of breast cancer cells to bone remains to be investigated.
dc.description.statementofresponsibilityMatthew T. Gillespie, Rachel J. Thomas, Zhao-Yan Pu, Hong Zhou, T. John Martin, David M. Findlay
dc.identifier.citationInternational Journal of Cancer, 1997; 73(6):812-815
dc.identifier.doi10.1002/(SICI)1097-0215(19971210)73:6<812::AID-IJC7>3.0.CO;2-5
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttp://hdl.handle.net/2440/6713
dc.language.isoen
dc.publisherWiley
dc.rights© 1997 Wiley-Liss, Inc.
dc.source.urihttps://doi.org/10.1002/(sici)1097-0215(19971210)73:6%3C812::aid-ijc7%3E3.0.co;2-5
dc.subjectTumor Cells, Cultured
dc.subjectHumans
dc.subjectCarcinoma, Ductal, Breast
dc.subjectBreast Neoplasms
dc.subjectSialoglycoproteins
dc.subjectReceptors, Calcitonin
dc.subjectRNA, Messenger
dc.subjectCytokines
dc.subjectIn Situ Hybridization
dc.subjectPolymerase Chain Reaction
dc.subjectFemale
dc.subjectOsteopontin
dc.subjectIntegrin-Binding Sialoprotein
dc.titleCalcitonin receptors, bone sialoprotein and osteopontin are expressed in primary breast cancers
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Orthopaedics and Trauma publications