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Positive thyroid peroxidase antibody and thyroglobulin antibody are associated with better clinicopathologic features of papillary thyroid cancer

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dc.contributor.authorLi, L.
dc.contributor.authorShan, T.
dc.contributor.authorSun, X.
dc.contributor.authorLv, B.
dc.contributor.authorChen, B.
dc.contributor.authorLiu, N.
dc.contributor.authorZhang, B.
dc.contributor.authorHu, S.
dc.contributor.authorZeng, Q.
dc.contributor.authorTurner, A.G.
dc.contributor.authorSheng, L.
dc.date.issued2021
dc.description.abstractObjective: To compare the thyroid autoantibody status of patients with papillary thyroid cancer (PTC) and benign nodular goiter as well as possible associations between thyroid autoantibodies and clinicopathologic features of PTC. Methods: A total of 3934 participants who underwent thyroidectomy were enrolled in this retrospective study. Patients were divided into PTC and benign nodule groups according to pathological diagnosis. Based on the preoperative serum antibody results, PTC patients were divided into thyroid peroxidase antibody (TPOAb)-positive, thyroglobulin antibody (TgAb)-positive, dual TPOAb- and TgAb-positive, or antibody-negative groups. Results: Of the 3934 enrolled patients, 2926 (74.4%) were diagnosed with PTC. Multivariate regression analyses suggested that high thyroid-stimulating hormone levels (adjusted odds ratio [OR] = 1.732, 95% CI [1.485-2.021], P < .001), positive TgAb (adjusted OR = 1.768, 95% CI [1.436-2.178], P < .001), and positive TPOAb (adjusted OR = 1.452, 95% CI [1.148-1.836], P = .002) were independent risk factors for predicting malignancy of thyroid nodules. Multinomial multiple logistic regression analyses indicated that positive TPOAb alone was an independent predictor of less central lymph node metastasis in PTC patients (adjusted OR = 0.643, 95% CI [0.448-0.923], P = .017), whereas positive TgAb alone was significantly associated with less extrathyroidal extension (adjusted OR = 0.778, 95% CI [0.622-0.974], P = .028). PTC patients with dual-positive TPOAb and TgAb displayed a decreased incidence of extrathyroidal extension (adjusted OR = 0.767, 95% CI [0.623-0.944], P = .012) and central lymph node metastasis (adjusted OR = 0.784, 95% CI [0.624-0.986], P = .037). Conclusion: Although preoperative positive TPOAb and TgAb are independent predictive markers for PTC, they are also associated with better clinicopathologic features of PTC.
dc.identifier.citationEndocrine Practice, 2021; 27(4):306-311
dc.identifier.doi10.1016/j.eprac.2020.10.017
dc.identifier.issn1530-891X
dc.identifier.issn1934-2403
dc.identifier.urihttps://hdl.handle.net/11541.2/25669
dc.language.isoen
dc.publisherAmerican Association of Clinical Endocrinologists
dc.rightsCopyright 2021 AACE. Published by Elsevier
dc.source.urihttps://doi.org/10.1016/j.eprac.2020.10.017
dc.subjectextrathyroidal extension
dc.subjectlymph node metastasis
dc.subjectPTC
dc.subjectTgAb
dc.subjectTPOAb
dc.titlePositive thyroid peroxidase antibody and thyroglobulin antibody are associated with better clinicopathologic features of papillary thyroid cancer
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916506093901831

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