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Feasibility of MRI assessment of maternal-fetal oxygen transport and consumption relative to maternal position in healthy late gestational pregnancies

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dc.contributor.authorSaini, B.S.
dc.contributor.authorDucas, R.
dc.contributor.authorDarby, J.R.T.
dc.contributor.authorMarini, D.
dc.contributor.authorSun, L.
dc.contributor.authorMacgowan, C.K.
dc.contributor.authorWindrim, R.
dc.contributor.authorKingdom, J.C.
dc.contributor.authorWald, R.M.
dc.contributor.authorMorrison, J.L.
dc.contributor.authorSeed, M.
dc.date.issued2023
dc.description.abstractAbstract: Late gestational supine positioning reduces maternal cardiac output due to inferior vena caval (IVC) compression, despite increased collateral venous return. However, little is known about the impact of maternal position on oxygen (O2) delivery and consumption of the gravid uterus, fetus, placenta and lower limbs. We studied the effects of maternal positioning on these parameters in 20 healthy pregnant subjects at 36 ± 2 weeks using magnetic resonance imaging (MRI); a follow-up MRI was performed 6-months postpartum (n = 16/20). MRI techniques included phase-contrast and T1/T2 relaxometry for blood flow and oximetry imaging, respectively. O2 transport was measured in the following vessels (bilateral where appropriate): maternal abdominal descending aorta (DAoabdo), IVC, ovarian, paraspinal veins (PSV), uterine artery (UtA) and external iliacs, and umbilical. Maternal cardiac output was measured by summing DAothoracic and superior vena cava flows. Supine mothers (n = 6) had lower cardiac output and O2 delivery in the DAoabdo, UtA and external iliac arteries, and higher PSV flow than those in either the left (n = 8) or right (n = 6) lateral positions during MRI. However, O2 consumption in the gravid uterus, fetus, placenta and lower limbs was unaffected by maternal positioning. The ratio of IVC/PSV flow decreased in supine mothers while ovarian venous flow and O2 saturation were unaltered, suggesting a major route of pelvic venous return unaffected by maternal position. Placental–fetal O2 transport and consumption were similar between left and right lateral maternal positions. In comparison to non-pregnant findings, DAoabdo and UtA O2 delivery and pelvic O2 consumption increased, while lower-limb consumption remained constant, despite reduced external iliac artery O2 delivery in late gestation. (Figure presented.). Key points: Though sleeping supine during the third trimester is associated with an increased risk of antepartum stillbirth, the underlying biological mechanisms are not fully understood. Maternal cardiac output and uteroplacental flow are reduced in supine mothers due to inferior vena caval compression from the weight of the gravid uterus. This MRI study provides a comprehensive circulatory assessment, demonstrating reduced maternal cardiac output and O2 delivery (uteroplacental, lower body) in supine compared to lateral positioning; however, O2 consumption (gravid uterus, fetus, placenta, lower limbs) was preserved. Unlike other mammalian species, the ovarian veins conduct substantial venous return from the human pregnant uterus that is unaffected by maternal positioning. Lumbar paraspinal venous flow increased in supine mothers. These observations may have important considerations during major pelvic surgery in pregnancy (i.e. placenta percreta). Future studies should address the importance of maternal positioning as a potential tool to deliver improved perinatal outcomes in pregnancies with compromised uteroplacental O2 delivery.
dc.identifier.citationJournal of Physiology, 2023; 601(23):5413-5436
dc.identifier.doi10.1113/JP285097
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793
dc.identifier.urihttps://hdl.handle.net/11541.2/36711
dc.language.isoen
dc.publisherWiley-Blackwell Publishing
dc.rightsCopyright 2023 The Authors. The Journal of Physiology Access Condition Notes: Accepted manuscript available after 01/01/2025
dc.source.urihttps://doi.org/10.1113/JP285097
dc.subjectblood flow
dc.subjectcardiac output
dc.subjectinferior vena cava compression
dc.subjectmaternal position
dc.subjectMRI oximetry
dc.subjectovarian vein
dc.titleFeasibility of MRI assessment of maternal-fetal oxygen transport and consumption relative to maternal position in healthy late gestational pregnancies
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12277659280001831 13277669050001831 Open Access Postprint
ror.mmsid9916803427101831

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