Avian influenza virus and DIVA strategies

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dc.contributor.authorHasan, N.
dc.contributor.authorIgnjatovic, J.
dc.contributor.authorPeaston, A.
dc.contributor.authorHemmatzadeh, F.
dc.date.issued2016
dc.description.abstractVaccination is becoming a more acceptable option in the effort to eradicate avian influenza viruses (AIV) from commercial poultry, especially in countries where AIV is endemic. The main concern surrounding this option has been the inability of the conventional serological tests to differentiate antibodies produced due to vacci- nation from antibodies produced in response to virus infection. In attempts to address this issue, at least six strategies have been formulated, aiming to differentiate infected from vaccinated animals (DIVA), namely (i) sentinel birds, (ii) subunit vaccine, (iii) heterologous neuraminidase (NA), (iv) nonstructural 1 (NS1) protein, (v) matrix 2 ectodomain (M2e) protein, and (vi) haemagglutinin subunit 2 (HA2) glycoprotein. This short review briefly discusses the strengths and limitations of these DIVA strategies, together with the feasibility and practicality of the options as a part of the surveillance program directed toward the eventual eradication of AIV from poultry in countries where highly pathogenic avian influenza is endemic.
dc.description.statementofresponsibilityNoor Haliza Hasan, Jagoda Ignjatovic, Anne Peaston, and Farhid Hemmatzadeh
dc.identifier.citationViral Immunology, 2016; 29(4):198-211
dc.identifier.doi10.1089/vim.2015.0127
dc.identifier.issn0882-8245
dc.identifier.issn1557-8976
dc.identifier.orcidPeaston, A. [0000-0002-7501-2415]
dc.identifier.orcidHemmatzadeh, F. [0000-0002-4572-8869]
dc.identifier.urihttp://hdl.handle.net/2440/99078
dc.language.isoen
dc.publisherMary Ann Liebert
dc.rights© Mary Ann Liebert, Inc.
dc.source.urihttps://doi.org/10.1089/vim.2015.0127
dc.subjectAnimals
dc.subjectChickens
dc.subjectInfluenza A virus
dc.subjectNeuraminidase
dc.subjectViral Nonstructural Proteins
dc.subjectHemagglutinin Glycoproteins, Influenza Virus
dc.subjectInfluenza Vaccines
dc.subjectAntibodies, Viral
dc.subjectSerologic Tests
dc.subjectVaccination
dc.subjectEndemic Diseases
dc.subjectInfluenza in Birds
dc.subjectEpidemiological Monitoring
dc.subjectSentinel Species
dc.titleAvian influenza virus and DIVA strategies
dc.typeJournal article
pubs.publication-statusPublished

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