Glycosylation of voltage-gated calcium channels in health and disease
Date
2017
Authors
Lazniewska, J.
Weiss, N.
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Journal Title
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Type:
Journal article
Citation
Biochimica et Biophysica Acta - Biomembranes, 2017; 1859(5):662-668
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Abstract
Voltage-gated calcium channels (VGCCs) are transmembrane proteins that translate electrical activities into intracellular calcium elevations and downstream signaling pathways. They serve essential physiological functions including communication between nerve cells, muscle contraction, cardiac activity, and release of hormones and neurotransmitters. Asparagine-linked glycosylation has emerged as an essential post-translational modification to control the number of channels embedded in the plasma membrane but also their functional gating properties.
This review provides a comprehensive overview about the current state of knowledge on the role of glycosylation in the expression and functioning of VGCCs, and discusses how variations in the glycosylation of the channel proteins can contribute to pathological conditions.
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Description
Data source: Supplementary material, https://doi.org/10.1016/j.bbamem.2017.01.018
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Copyright 2017 Elsevier B.V.
Access Condition Notes: As per publisher website available freely after embargo period of 12 months