Naturally derived iron oxide nanowires from bacteria for magnetically triggered drug release and cancer hyperthermia in 2D and 3D culture environments: bacteria Bbiofilm to potent cancer therapeutic

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dc.contributor.authorKumeria, T.
dc.contributor.authorMaher, S.
dc.contributor.authorWang, Y.
dc.contributor.authorKaur, G.
dc.contributor.authorWang, L.
dc.contributor.authorErkelens, M.
dc.contributor.authorForward, P.
dc.contributor.authorLambert, M.
dc.contributor.authorEvdokiou, A.
dc.contributor.authorLosic, D.
dc.date.issued2016
dc.description.abstractIron oxide nanowires produced by bacteria (Mariprofundus ferrooxydans) are demonstrated as new multifunctional drug carriers for triggered therapeutics release and cancer hyperthmia applications. Iron oxide nanowires are obtained from biofilm waste in the bore system used to pump saline groundwater into the River Murray, South Australia (Australia) and processed into individual nanowires with extensive magnetic properties. The drug carrier capabilities of these iron oxide nanowires (Bac-FeOxNWs) are assessed by loading anticancer drug (doxorubicin, Dox) followed by measuring its elution under sustained and triggered release conditions using alternating magnetic field (AMF). The cytotoxicity of Bac-FeOxNWs assessed in 2D (96 well plate) and 3D (Matrigel) cell cultures using MDA-MB231-TXSA human breast cancer cells and mouse RAW 264.7 macrophage cells shows that these Bac-FeOxNWs are biocompatible even at concentrations as high as 250 μg/mL after 24 h of incubation. Finally, we demonstrate the capabilities of Bac-FeOxNWs as potential hyperthermia agent in 3D culture setup. Application of AMF increased the local temperature by 14 °C resulting in approximately 34% decrease in cell viability. Our results demonstrate that these naturally produced nanowires in the form of biofilm can efficiently act as drug carriers with triggered payload release and magnetothermal heating features for potential anticancer therapeutics applications.
dc.description.statementofresponsibilityTushar Kumeria, Shaheer Maher, Ye Wang, Gagandeep Kaur, Luoshan Wang, Mason Erkelens, Peter Forward, Martin F. Lambert, Andreas Evdokiou, and Dusan Losic
dc.identifier.citationBiomacromolecules, 2016; 17(8):2726-2736
dc.identifier.doi10.1021/acs.biomac.6b00786
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.orcidMaher, S. [0000-0002-2556-1096]
dc.identifier.orcidLambert, M. [0000-0001-8272-6697]
dc.identifier.orcidEvdokiou, A. [0000-0001-8321-9806]
dc.identifier.orcidLosic, D. [0000-0002-1930-072X]
dc.identifier.urihttp://hdl.handle.net/2440/102585
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.granthttp://purl.org/au-research/grants/arc/DP120101680
dc.relation.granthttp://purl.org/au-research/grants/arc/FT110100711
dc.relation.granthttp://purl.org/au-research/grants/arc/DE140100549
dc.rights© 2016 American Chemical Society
dc.source.urihttp://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b00786
dc.subjectCells, Cultured
dc.subjectMacrophages
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectBacteria
dc.subjectBiofilms
dc.subjectBreast Neoplasms
dc.subjectFever
dc.subjectFerric Compounds
dc.subjectDoxorubicin
dc.subjectAntibiotics, Antineoplastic
dc.subjectDrug Carriers
dc.subjectCombined Modality Therapy
dc.subjectCell Culture Techniques
dc.subjectCell Survival
dc.subjectMagnetics
dc.subjectFemale
dc.subjectNanowires
dc.subjectDrug Liberation
dc.titleNaturally derived iron oxide nanowires from bacteria for magnetically triggered drug release and cancer hyperthermia in 2D and 3D culture environments: bacteria Bbiofilm to potent cancer therapeutic
dc.typeJournal article
pubs.publication-statusPublished

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