Remodelling of high density lipoproteins by plasma factors / by Hui-Qi Liang.
Date
1996
Authors
Liang, Hui-Qi
Editors
Advisors
Journal Title
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Type:
Thesis
Citation
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Abstract
This thesis examines the effect of remodelling HDL on the metabolism of apo A-I. The major focus is on the effects of CETP and LCAT in the regulation of apo A-I concentration in DHL. The effects of incubation of HDL with CETP in the presence of VLDL and/or LDL on apo A-I concentration in HDL are examined. The characterization of the dissociated apo A-I from HDL is presented. The studies demonstrate that the dissociation of apo A-I from HDL mediated by CETP is preventable and reversible in a process dependent on LCAT activity. The mechanism by which HDL apo A-I content is increased is also explored.
School/Discipline
Dept. of Medicine
Dissertation Note
Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1997?
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Description
Bibliography: leaves 105-151.
xi, 151, [47] leaves, [3] leaves of plates : ill. ; 30 cm.
xi, 151, [47] leaves, [3] leaves of plates : ill. ; 30 cm.