Estimation of sinusoidal flow heterogeneity in normal and diseased rat livers from tracer dilution data using a fractal model
| dc.contributor.author | Weise, M. | |
| dc.contributor.author | Li, P. | |
| dc.contributor.author | Roberts, M.S. | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Objectives: Up to now, vascular indicator-dilution curves have been analyzed by numerical integration or by fitting empirical functions to the data. Here, we apply a recently developed mechanistic model with the goal to quantitatively describe flow distribution in the sinusoidal network of normal rat livers and those with high-fat emulsion-induced NASH. Methods: Single-pass outflow concentration data of sucrose were obtained from in situ perfused rat livers after impulse injection. The model fitted to the data consists of a continuous mixture of inverse Gaussian densities assuming a normal distribution of regional flow. It accounts for the fractal flow heterogeneity in the organ and has three adjustable parameters with a clear physiological interpretation. Results: The model fitted the data well and revealed that the intrahepatic flow dispersion of 49.6 % in the control group increased significantly to 87.2 % in the NASH group (p < 0.01). In contrast to previously used empirical functions, the present model exhibits a power-law tail (∼t−2.4), which is a signature of fractal microvascular networks. Conclusions: The approach offers the possibility to determine hepatic blood flow heterogeneity in perfused livers and to evaluate the functional implications. | |
| dc.identifier.citation | Microcirculation, 2012; 19(8):723-728 | |
| dc.identifier.doi | 10.1111/j.1549-8719.2012.00208.x | |
| dc.identifier.issn | 1073-9688 | |
| dc.identifier.issn | 1549-8719 | |
| dc.identifier.uri | https://hdl.handle.net/1959.8/125158 | |
| dc.language.iso | en | |
| dc.publisher | John Wiley & Sons | |
| dc.relation.funding | NHMRC 569710 | |
| dc.relation.funding | Deutsche Forschungsgemeinschaft WE 2190/5-2 | |
| dc.rights | Copyright 2012 John Wiley & Sons | |
| dc.source.uri | https://doi.org/10.1111/j.1549-8719.2012.00208.x | |
| dc.subject | flow distribution | |
| dc.subject | fractal heterogeneity | |
| dc.subject | indicator dilution | |
| dc.subject | liver | |
| dc.subject | nonalcoholic steatohepatitis | |
| dc.title | Estimation of sinusoidal flow heterogeneity in normal and diseased rat livers from tracer dilution data using a fractal model | |
| dc.type | Journal article | |
| pubs.publication-status | Published | |
| ror.mmsid | 9915909794901831 |