Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

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dc.contributor.authorBrotherton, P.
dc.contributor.authorHaak, W.
dc.contributor.authorTempleton, J.
dc.contributor.authorSoubrier, J.
dc.contributor.authorAdler, C.
dc.contributor.authorRichards, S.
dc.contributor.authorDersarkissian, C.
dc.contributor.authorCooper, A.
dc.date.issued2013
dc.description.abstractHaplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (~5450 BC) and Bronze Age (~2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (~4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (~2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.
dc.description.statementofresponsibilityPaul Brotherton, Wolfgang Haak, Jennifer Templeton, Guido Brandt, Julien Soubrier, Christina Jane Adler, Stephen M. Richards, Clio Der Sarkissian, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Mannis van Oven, Rosalie Kenyon, Mark B. Van der Hoek, Jonas Korlach, Khai Luong, Simon Y.W. Ho, Lluis Quintana-Murci, Doron M. Behar, Harald Meller, Kurt W. Alt, Alan Cooper & The Genographic Consortium
dc.identifier.citationNature Communications, 2013; 4(1764):1-11
dc.identifier.doi10.1038/ncomms2656
dc.identifier.issn2041-1723
dc.identifier.issn2041-1723
dc.identifier.orcidHaak, W. [0000-0003-2475-2007]
dc.identifier.orcidSoubrier, J. [0000-0001-9350-7369]
dc.identifier.orcidRichards, S. [0000-0002-0202-9654] [0000-0002-7604-2368]
dc.identifier.orcidCooper, A. [0000-0002-7738-7851]
dc.identifier.urihttp://hdl.handle.net/2440/80204
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.granthttp://purl.org/au-research/grants/arc/LP0882622
dc.relation.granthttp://purl.org/au-research/grants/arc/LP0882622
dc.rights© 2013 Macmillan Publishers Limited. All rights reserved
dc.source.urihttps://doi.org/10.1038/ncomms2656
dc.subjectGenographic Consortium
dc.subjectHumans
dc.subjectSequence Analysis, DNA
dc.subjectGenetics, Population
dc.subjectDemography
dc.subjectEvolution, Molecular
dc.subjectPhylogeny
dc.subjectBase Sequence
dc.subjectHaplotypes
dc.subjectGenome, Human
dc.subjectPrincipal Component Analysis
dc.subjectTime Factors
dc.subjectMolecular Sequence Data
dc.subjectGenome, Mitochondrial
dc.subjectWhite People
dc.titleNeolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans
dc.typeJournal article
pubs.publication-statusPublished

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