Polymeric monoliths for the size separation of large biomolecules /
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(Published version)
Date
2024
Authors
de Wal, Laura
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Type:
thesis
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Abstract
With seven out of the ten bestselling therapeutics being protein-based, there is a growing interest in biotherapeutics over small molecule drugs. However, the application of the biotherapeutic technology is stalled by the lack of effective methods to transport these biotherapeutics safely and protectively to the disease site. One possibility to overcome the challenges of drug delivery is by the encapsulation of biotherapeutics in nanoparticles. The biodistribution and efficacy of nanoparticles relies significantly on their size properties. This, together with the increasing interest in biotherapeutics, means there is a need for new analytical methods that can support the development of biotherapeutics and nanoparticles to ensure safety for new therapies. One method of interest is size exclusion chromatography.
School/Discipline
University of South Australia. UniSA STEM.
UniSA STEM
UniSA STEM
Dissertation Note
Thesis (PhD(Environmental Science and Engineering))--University of South Australia, 2024.
Provenance
Copyright 2024 Laura de Wal
Description
1 ethesis (xix, 159 pages) :
colour illustrations, colour charts.
Includes bibliographical references (pages 123-137)
colour illustrations, colour charts.
Includes bibliographical references (pages 123-137)
Access Status
506 0#$fstar $2Unrestricted online access