Mapping quantitative trait loci for feed efficiency in mice - a preliminary analysis
Date
2001
Authors
Hebart, M.
Bottema, C.
Pitchford, W.
Editors
Neville Jepson,
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Conference paper
Citation
Association for the Advancement of Animal Breeding and Genetics. Proceedings, 2001; 14:179-182
Statement of Responsibility
M.L. Fenton, C.D.K. Bottema, and W.S. Pitchford
Conference Name
Conference of the Association for the Advancement of Animal Breeding & Genetics (14th : 2001 : Queenstown, New Zealand)
Abstract
Mice from high and low feed efficiency selection lines were used in an F₂ mapping design. The mouse lines differed in feed intake by approximately 25% with only small differences in growth and body composition. One hundred and twenty progeny from 2 F₁ sires were selectively genotyped. A genome scan was done using 80 microsatellite markers evenly spaced every 20cM throughout the genome. A preliminary analysis using an analysis of variance resulted in the following 16 putative quantitative trait loci (QTL) (F Prob<0.01): three for net feed intake, one for daily feed intake, four for body fat %, three for average daily gain and five for metabolic mid-weight. A QTL affecting fat and weight mapped to the same region (chromosome 13) as other mouse studies.