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Frequency-dependent, bi-directional plasticity in motor cortex of human adults

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dc.contributor.authorPitcher, J.
dc.contributor.authorRidding, M.
dc.contributor.authorMiles, T.
dc.date.issued2003
dc.descriptionCopyright © 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ireland Ltd.
dc.description.abstractObjective: To determine whether the plastic changes induced in human motor cortex by afferent stimulation depend on stimulus frequency. Methods: Transcranial magnetic stimulation was used to examine changes in corticospinal excitability in 20 subjects before and after combined peripheral (motor point) and central stimulation. Peripheral stimuli were given as either low frequency (3 Hz) or high frequency (30 Hz) trains. Results: Low frequency stimulation induced prolonged depression of corticospinal excitability, while high frequency stimulation induced prolonged facilitation. These effects persisted for approximately 40–50 min after stimulation ceased. Conclusions: Corticospinal plasticity induced by dual peripheral and central stimulation is bi-directionally-modifiable in the adult human, with the direction of change being frequency-dependent. Significance: Therapies using peripheral stimulation to alter human motor cortex excitability could be tailored to exploit the differential effects of stimulus frequency on the direction of the excitability change.
dc.description.statementofresponsibilityJulia B. Pitcher, Michael C. Ridding and Timothy S. Miles
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/601528/description#description
dc.identifier.citationClinical Neurophysiology, 2003; 114(7):1265-1271
dc.identifier.doi10.1016/S1388-2457(03)00092-0
dc.identifier.issn1388-2457
dc.identifier.issn1872-8952
dc.identifier.orcidPitcher, J. [0000-0002-9648-7540]
dc.identifier.orcidRidding, M. [0000-0001-5657-9136]
dc.identifier.urihttp://hdl.handle.net/2440/2957
dc.language.isoen
dc.publisherElsevier Sci Ireland Ltd
dc.source.urihttps://doi.org/10.1016/s1388-2457(03)00092-0
dc.subjectMotor Cortex
dc.subjectHumans
dc.subjectElectromyography
dc.subjectAnalysis of Variance
dc.subjectElectric Stimulation
dc.subjectDifferential Threshold
dc.subjectDose-Response Relationship, Radiation
dc.subjectEvoked Potentials, Motor
dc.subjectNeuronal Plasticity
dc.subjectMagnetics
dc.subjectTime Factors
dc.subjectAdolescent
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleFrequency-dependent, bi-directional plasticity in motor cortex of human adults
dc.typeJournal article
pubs.publication-statusPublished

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