Physicochemical and biopharmaceutical investigations of novel drug delivery systems for oral administration of poorly water-soluble drugs: silica-lipid hybrid microcapsules /
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(Published version)
Date
2010
Authors
Tan, Angel,
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thesis
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Abstract
Formulation of poorly water-soluble and lipophilic drugs in lipid-based delivery system is recognised as a potential strategy for improving their oral absorption. With only 2–4% oral lipid-based formulations available in the pharmaceutical market worldwide, the development of lipid-based products is clearly behind the rate of discovery of new chemical entities exhibiting poor aqueous solubility. A novel silica-lipid hybrid (SLH) microcapsule system for enhancing the oral absorption of low solubility and high permeability (BCS Class II) drugs has been developed and demonstrated for the model drug celecoxib (CEL). This thesis describes (i) the fabrication of the SLH microcapsule system, (ii) the systematic in vitro characterisation of its dissolution and lipolysis properties and (iii) the in vivo pharmacokinetic investigation of various CEL formulations in a rat model.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences
School of Pharmacy and Medical Sciences
School of Pharmacy and Medical Sciences
Dissertation Note
Thesis (PhDPharmacy)--University of South Australia, 2010.
Provenance
Copyright 2010 Angel Tan. This item has been reproduced by the University of South Australia here in good faith. Attempts to contact original copyright owner(s) are ongoing. We would be pleased to hear from copyright owner(s).
Description
xvi, 197 leaves :
illustrations (chiefly colour).
Includes bibliographic references.
illustrations (chiefly colour).
Includes bibliographic references.
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506 0#$fstar $2Unrestricted online access