Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy

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dc.contributor.authorLarson-Meyer, D.
dc.contributor.authorSmith, S.
dc.contributor.authorHeilbronn, L.
dc.contributor.authorKelley, D.
dc.contributor.authorRavussin, E.
dc.contributor.authorNewcomer, B.
dc.date.issued2006
dc.description.abstractObjective: Muscle triglyceride can be assessed in vivo using computed tomography (CT) and 1H magnetic resonance spectroscopy (MRS), two techniques that are based on entirely different biophysical principles. Little is known, however, about the cross-correlation between these techniques and their test–retest reliability. Research Methods and Procedures: We compared mean muscle attenuation (MA) in soleus and tibialis anterior (TA) muscles measured by CT with intra- and extramyocellular lipids (IMCL and EMCL, respectively) measured by MRS in 51 volunteers (26 to 72 years of age, BMI = 25.5 to 39.3 kg/m2). MA of midthighs was also measured in a subset (n = 19). Test–retest measurements were performed by CT (n = 6) and MRS (n = 10) in separate sets of volunteers. Results: MA of soleus was significantly associated with IMCL (r = - 0.64) and EMCL, which by multiple regression analysis was explained mostly by IMCL (p < 0.001) rather than EMCL (beta = - 0.010, p = 0.94). Muscle triglyceride was lower in TA than in soleus, and MA of TA was significantly correlated with EMCL (r = - 0.40) but not IMCL (r = - 0.16). By CT, MA of midthighs was correlated with MA in soleus (r = 0.40, p = 0.07) and whole calf (r = 0.62, p < 0.05). Finally, both MA and IMCL were highly reliable in soleus (coefficient of variation = <2% and 6.7%, respectively) and less reliable in TA (4% and 10%, respectively). Discussion: These results support the use of both CT and MRS as reliable methods for assessing skeletal muscle lipid.
dc.description.statementofresponsibilityD. Enette Larson-Meyer, Steven R. Smith, Leonie K. Heilbronn, David E. Kelley, Eric Ravussin, Bradley R. Newcomer, and the Look AHEAD Adipose Research Group
dc.identifier.citationObesity, 2006; 14(1):73-87
dc.identifier.doi10.1038/oby.2006.10
dc.identifier.issn1930-7381
dc.identifier.issn1930-739X
dc.identifier.orcidHeilbronn, L. [0000-0003-2106-7303]
dc.identifier.urihttp://hdl.handle.net/2440/64898
dc.language.isoen
dc.publisherNorth Amer Assoc Study Obesity
dc.rightsCopyright © 2006 NAASO
dc.source.urihttps://doi.org/10.1038/oby.2006.10
dc.subjecttest–retest repeatability/reliability
dc.subject¹H magnetic resonance spectroscopy normalization
dc.subjectintramyocellular lipid
dc.subjectextramyocellular lipid
dc.subjectcomputed tomography attenuation
dc.titleMuscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy
dc.typeJournal article
pubs.publication-statusPublished

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