A comparison of radiostereometric analysis and computed tomography for the assessment of lumbar spinal fusion in a sheep model

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dc.contributor.authorHumadi, A.
dc.contributor.authorFreeman, B.
dc.contributor.authorMoore, R.
dc.contributor.authorCallary, S.
dc.contributor.authorHalldin, K.
dc.contributor.authorDavid, V.
dc.contributor.authorMaclaurin, W.
dc.contributor.authorTauro, P.
dc.contributor.authorScoenwaelder, M.
dc.date.issued2013
dc.description.abstractObjective: The aim of this animal study is to evaluate the accuracy of radiostereometric analysis (RSA) compared with computed tomographic (CT) scan in the assessment of spinal fusion after anterior lumbar interbody fusion (ALIF) using histology as a gold standard. Methods: Three non-adjacent ALIFs (L1–L2, L3–L4, and L5–L6) were performed in nine sheep. The sheep were divided into three groups of three sheep. All the animals were humanely killed immediately after having the last scheduled RSA. The lumbar spine was removed and in vitro fine cut CT and histopathology were performed. Results: Using histological assessment as the gold standard for assessing fusion, RSA demonstrated better results (100% sensitivity and 66.7% specificity; positive predictive value [PPV] = 27.3%, negative predictive value [NPV] =100.0%) compared with CT (66.7% sensitivity and 60.0% specificity [PPV = 16.7%, NPV = 93.8%]). Conclusions: RSA demonstrated higher sensitivity and specificity when compared with CT. Furthermore, RSA has the advantage of much lower radiation exposure compared with fine cut CT. Further studies are required to see if RSA remains superior to CT scan for the assessment spinal fusion in the clinical setting.
dc.description.statementofresponsibilityAli Humadi, Brian J. C. Freeman, Rob J. Moore, Stuart Callary, Klas Halldin, Vikram David, William Maclaurin, Paul Tauro, Mark Schoenwaelder
dc.identifier.citationEvidence-Based Spine-Care Journal, 2013; 4(2):78-89
dc.identifier.doi10.1055/s-0033-1357359
dc.identifier.issn1663-7976
dc.identifier.issn1869-4136
dc.identifier.orcidFreeman, B. [0000-0003-0237-9707]
dc.identifier.orcidCallary, S. [0000-0002-2892-5238]
dc.identifier.urihttp://hdl.handle.net/2440/85704
dc.language.isoen
dc.publisherThieme Medical Publishers
dc.rights© 2013, Rights Managed by Georg Thieme Verlag KG Stuttgart
dc.source.urihttps://doi.org/10.1055/s-0033-1357359
dc.subjectradiostereometric analysis; spinal fusion; assessment; computed tomography; histology
dc.titleA comparison of radiostereometric analysis and computed tomography for the assessment of lumbar spinal fusion in a sheep model
dc.typeJournal article
pubs.publication-statusPublished

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