Accelerating protein release from microparticles for regenerative medicine applications
Date
2013
Authors
White, L.J.
Kirby, G.T.S.
Cox, H.C.
Qodratnama, R.
Qutachi, O.
Rose, F.R.A.J.
Shakesheff, K.M.
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Journal article
Citation
Materials Science and Engineering C, 2013; 33(5):2578-2583
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Abstract
There is a need to control the spatio-temporal release kinetics of growth factors in order to mitigate current usage of high doses. A novel delivery system, capable of providing both structural support and controlled release kinetics, has been developed from PLGA microparticles. The inclusion of a hydrophilic PLGA-PEG-PLGA triblock copolymer altered release kinetics such that they were decoupled from polymer degradation. A quasi zero order release profile over four weeks was produced using 10% w/w PLGA-PEG-PLGA with 50:50 PLGA whereas complete and sustained release was achieved over ten days using 30% w/w PLGA-PEG-PLGA with 85:15 PLGA and over four days using 30% w/w PLGA-PEG-PLGA with 50:50 PLGA. These three formulations are promising candidates for delivery of growth factors such as BMP-2, PDGF and VEGF. Release profiles were also modified by mixing microparticles of two different formulations providing another route, not previously reported, for controlling release kinetics. This system provides customisable, localised and controlled delivery with adjustable release profiles, which will improve the efficacy and safety of recombinant growth factor delivery.
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Copyright 2012 Elsevier BV.This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (https://s100.copyright.com/AppDispatchServlet?publisherName=ELS&contentID=S0928493113001203&orderBeanReset=true)