General Practice

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The Discipline of General Practice is part of the School of Population Health and Clinical Practice

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Browsing General Practice by Author "Acres, J."

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    B-vitamins reduce plasma levels of beta amyloid
    (Elsevier Science Inc, 2008) Flickera, L.; Martins, R.; Thomas, J.; Acres, J.; Taddei, K.; Vasikaran, S.; Norman, P.; Jamrozik, K.; Almeida, O.
    Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.
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    Predictors of impaired cognitive function in men over the age of 80 years: results from the Health in Men Study
    (Oxford Univ Press, 2005) Flicker, L.; Almeida, O.; Acres, J.; Le, M.; Tuohy, R.; Jamrozik, K.; Hankey, G.; Norman, P.