Anaesthesia and Intensive Care publications
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Item Metadata only Carbon monoxide. From toxic poison to brain messenger(South Pacific Underwater Medicine Society, 1995) Gorman, D. F.Item Metadata only The principles of health assessment and health surveillance(South Pacific Underwater Medicine Society, 1995) Gorman, D. F.Item Metadata only Draft SPUMS policy on certification of diver fitness(South Pacific Underwater Medicine Society, 1995) Veale, A. G.; Gorman, D. F.; Richardson, D.Item Metadata only Success of Surf Life Saving resuscitations in Queensland 1972-1992(Australian Medical Publishing Co. Ltd, 1995) Fenner, Peter J.; Harrison, S. L.; Williamson, John Aubrey Henry; Williamson, B.Item Open Access Problems in the modelling of inert gas kinetics(Australian Society of Anaesthetists, 1995) Gorman, Desmond FrancisItem Metadata only Yet another fuss about (probably) nothing(South Pacific Underwater Medicine Society, 1995) Gorman, D. F.Item Metadata only The quality in Australian health care study(Australian Medical Publishing Co. Ltd, 1995) Wilson, R.; Runciman, W.; Gibberd, R.; Harrison, B.; Newby, L.; Hamilton, J.Item Metadata only Prevention of venous air embolism: Are humans like sheep?(Macmillan Journals, 1995) Pfitzner, JohnItem Metadata only Clinical toxicology of marine coelenterate injuries(CRC Press, 1995) Williamson, John Aubrey Henry; Burnett, Jim; School of Medicine : Anaesthesia and Intensive CareItem Metadata only Problems in the modelling of inert gas kinetics(South Pacific Underwater Medicine Society, 1995) Gorman, D. F.Item Open Access Video assisted thorascoscopy for spontaneous haemopneumothorax(Australian Society of Anaesthetists, 1995) Barry, J. J.; Pfitzner, John; Peacock, Morris J.; School of Medicine : Anaesthesia and Intensive CareItem Metadata only SPUMS policy on asthma and diving(South Pacific Underwater Medicine Society, 1995) Gorman, D. F.; Veale, A. G.Item Metadata only Near infrared spectroscopy in severe head injury: A comparison with jugular bulb oximetry(Australian Society of Anaesthetists, 1995) Lewis, S.; Myburgh, J.; Reilly, P.Item Metadata only Hyperexcitability in CA1 of the rat hippocampal slice following hypoxia or adenosine(Elsevier Science B.V., 1995) Doolette, David J.; Kerr, David Ian BevissItem Metadata only Clinical toxicology of venomous Scorpaenindae and other selected fish stings(CRC Press, 1995) Williamson, John Aubrey Henry; School of Medicine : Anaesthesia and Intensive CareItem Metadata only Complete retrograde dysmnesia(Society for Technology in Anesthesia, 1995) Runciman, W.Item Metadata only 3-Amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide, a new class of GABAB receptor antagonist in central and peripheral preparations(North Holland, 1995) Kerr, D.; Ong, J.; Hughes, R.; Prager, R.Racemic 3-amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide (AHPNS), a sulphonamide analog of GABA, reversibly and competitively antagonised the concentration-dependent depression of cholinergic twitch contractions by baclofen, in the electrically stimulated guinea-pig isolated ileum, with a pA2 of 4.0 +/- 0.2. In the rat neocortex, maintained in Mg(2+)-free medium, AHPNS (100-500 microM) also reversibly antagonised the baclofen (10 microM)-induced suppression of spontaneous discharges. AHPNS is a new class of GABAB receptor antagonist that has central and peripheral blocking actions.Item Metadata only A method for frequent measurement of sedation and analgesia in sheep using the response to a ramped electrical stimulus(Elsevier, 1995) Ludbrook, G.; Grant, C.; Upton, R.; Penhall, C.A method for the frequent, precise measurement of the analgesic and sedative (or anesthetic) effects of drugs after bolus administration to sheep was developed. A ramped pulsed DC electrical stimulus was delivered to the hind limb of sheep via subcutaneous needles by use of a peripheral nerve stimulator modified to allow control of current ramp rate and pulse frequency, and limb withdrawal was used as an endpoint. The optimal stimulus pattern was found to be a pulse frequency of 20 Hz, with a 5-sec ramp time and measurement intervals of 30 sec. The effects of a range of analgesic and sedative drugs on the threshold current to produce limp withdrawal were examined. Administration of the sedative/anesthetic drugs propofol and thiopentone intravenously and of the analgesic xylazine both intravenously and intramuscularly resulted in a reproducible dose-dependent rise in the threshold current required to produce limb withdrawal. Administration of the opioids alfentanil and pethidine produced agitation, making measurements unreliable. It is concluded that this device allows repeated reproducible measurements of analgesia and sedation to be made in sheep at a frequency sufficient to characterize the initial effects of analgesic and sedative drugs, particularly after intravenous administration.Item Metadata only Interactions of N-ethylmaleimide and aluminium fluoride with GABAB receptor function in rat neocortical slices(North Holland, 1995) Ong, J.; Kerr, D.Interactions of N-ethylmaleimide and aluminium fluoride (AlF - 4) with GABAB receptors have been examined using spontaneously discharging rat neocortical slices. The suppression of discharges by the GABAB receptor agonist baclofen (5-10 mu M) was irreversibly prevented by N-ethylmaleimide (10-50 mu M) and its analog N-phenylmaleimide (10-50 mu M), whilst superfusion of slices with NaF (10 mM) and AlCl3 (100 mu M) to form a fluoroaluminate (AlF - 4) complex markedly potentiated the action of baclofen. The lipoxygenase inhibitors, nordihydroguaiaretic acid (10-50 mu M) and eicosatetraynoic acid (10-50 mu M) or the phospholipase A2 inhibitor bromophenacylbromide (50-100 mu M) did not affect the response to baclofen. The depressant action of baclofen is evidently mediated through G-proteins, but is not dependent on arachidonic acid metabolites.Item Metadata only Cerebral arterial fat embolism in the rabbit(Elsevier Science B.V., 1995) Drew, P.; Helps, S.; Smith, E.This study was designed to measure the effects of cerebral arterial fat embolism on cerebral blood flow and function. Rabbits were injected via the left internal carotid artery with the neutral triglyceride triolein. Left cerebral blood flow was measured by laser Doppler flowmetry, and left sided brain function by electrocorticogram and cortical somatosensory evoked responses following electrical stimulation of the forepaw. Readings were taken for 2 h before injection to establish a baseline, and for 3 h after injection. Cerebral blood flow was significantly decreased at 45 min after the injection of the lipid, then progressively decreased further to approximately 50% of baseline after 2 h, at which level it remained for the last hour of the experiment. The electrocorticogram was rapidly, but transiently, suppressed. The evoked responses did not differ from baseline at each of the time points measured. Using 125I-triolein, 2.49% of the injected dose was measured in the brain 3 min after injection. The results show that in this rabbit model of cerebral arterial fat embolism only a small percentage of injected lipid passes into the brain, but this is sufficient to cause a reduction in cerebral blood flow over the following 2 h. The evoked responses never alter significantly from baseline values.