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Type: Journal article
Title: The interplay between surface nanotopography and chemistry modulates collagen I and III deposition by human dermal fibroblasts
Author: Bachhuka, A.
Hayball, J.
Smith, L.
Vasilev, K.
Citation: ACS Applied Materials and Interfaces, 2017; 9(7):5874-5884
Publisher: American Chemical Society
Issue Date: 2017
ISSN: 1944-8244
Statement of
Akash Bachhuka, John Dominic Hayball, Louise E. Smith and Krasimir Vasilev
Abstract: The events within the foreign body response are similar to, but ultimately different than, the wound healing cascade. Collagen production by fibroblasts is known to play a vital role in wound healing and device fibrous encapsulation. However, the influence of surface nanotopography on collagen deposition by these cells has not been reported so far. To address this gap, we have developed model substrata having surface nanotopography of controlled height of 16, 38, and 68 nm and tailored outermost surface chemistry of amines, carboxyl acid, and pure hydrocarbon. Fibroblast adhesion was reduced on nanotopographically modified surfaces compared to the smooth control. Furthermore, amine and acid functionalized surfaces showed increased cell proliferation over hydrophobic hydrocarbon surfaces. Collagen III production increased from day 3 to day 8 and then decreased from day 8 to day 16 on all surfaces, while collagen I deposition increased throughout the duration of 16 days. Our data show that the initial collagen I and III deposition can be modulated by selecting desired combinations of surface nanotopography and chemistry. This study provides useful knowledge that could help in tuning fibrous capsule formation and in turn govern the fate of implantable biomaterial devices.
Keywords: Biomaterials
collagens I and III
foreign body response
plasma polymerization
surface nanotopography
Rights: Copyright © 2017 American Chemical Society
DOI: 10.1021/acsami.6b15932
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