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https://hdl.handle.net/2440/105752
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Type: | Journal article |
Title: | Subjective well-being in older adults: folate and vitamin B₁₂ independently predict positive affect |
Author: | Edney, L. Burns, N. Danthiir, V. |
Citation: | The British Journal of Nutrition: an international journal of nutritional science, 2015; 114(8):1321-1328 |
Publisher: | Cambridge University Press |
Issue Date: | 2015 |
ISSN: | 0007-1145 1475-2662 |
Statement of Responsibility: | Laura C. Edney, Nicholas R. Burns and Vanessa Danthiir |
Abstract: | Vitamin B₁₂, folate and homocysteine have long been implicated in mental illness, and growing evidence suggests that they may play a role in positive mental health. Elucidation of these relationships is confounded due to the dependence of homocysteine on available levels of vitamin B₁₂ and folate. Cross-sectional and longitudinal relationships between vitamin B₁₂, folate, homocysteine and subjective well-being were assessed in a sample of 391 older, community-living adults without clinically diagnosed depression. Levels of vitamin B₁₂, but not folate, influenced homocysteine levels 18 months later. Vitamin B₁₂, folate and their interaction significantly predicted levels of positive affect (PA) 18 months later, but had no impact on the levels of negative affect or life satisfaction. Cross-sectional relationships between homocysteine and PA were completely attenuated in the longitudinal analyses, suggesting that the cross-sectional relationship is driven by the dependence of homocysteine on vitamin B₁₂ and folate. This is the first study to offer some evidence of a causal link between levels of folate and vitamin B₁₂ on PA in a large, non-clinical population. |
Keywords: | Folate; homocysteine; positive affect; subjective well-being; vitamin B12 |
Rights: | © The Authors 2015 |
DOI: | 10.1017/S0007114515002949 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/578800 |
Published version: | http://dx.doi.org/10.1017/s0007114515002949 |
Appears in Collections: | Aurora harvest 8 Psychology publications |
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