Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107493
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Type: Journal article
Title: Developing consensus-based priority outcome domains for trials in kidney transplantation: a multinational Delphi Survey with patients, caregivers, and health professionals
Author: Sautenet, B.
Tong, A.
Manera, K.
Chapman, J.
Warrens, A.
Rosenbloom, D.
Wong, G.
Gill, J.
Budde, K.
Rostaing, L.
Marson, L.
Josephson, M.
Reese, P.
Pruett, T.
Hanson, C.
O'Donoghue, D.
Tam-Tham, H.
Halimi, J.
Shen, J.
Kanellis, J.
et al.
Citation: Transplantation, 2017; 101(8):1875-1886
Publisher: Lippincott Williams & Wilkins
Issue Date: 2017
ISSN: 0041-1337
1534-6080
Statement of
Responsibility: 
Bénédicte Sautenet ... Shilpa Jesudason ... Stephen P. McDonald ... et al.
Abstract: Background. Inconsistencies in outcome reporting and frequent omission of patient-centered outcomes can diminish the value of trials in treatment decision making. We identified critically important outcome domains in kidney transplantation based on the shared priorities of patients/caregivers and health professionals. Methods. In a 3-round Delphi survey, patients/caregivers and health professionals rated the importance of outcome domains for trials in kidney transplantation on a 9-point Likert scale and provided comments.During rounds 2 and 3, participants rerated the outcomes after reviewing their own score, the distribution of the respondents' scores, and comments. We calculated the median, mean, and proportion rating 7 to 9 (critically important), and analyzed comments thematically. Results. One thousand eighteen participants (461 [45%] patients/caregivers and 557 [55%] health professionals) from 79 countries completed round 1, and 779 (77%) completed round 3. The top 8 outcomes that met the consensus criteria in round 3 (mean, ≥7.5; median, ≥8; proportion, >85%) in both groups were graft loss, graft function, chronic rejection, acute rejection, mortality, infection, cancer (excluding skin), and cardiovascular disease. Compared with health professionals, patients/caregivers gave higher priority to 6 outcomes (mean difference of 0.5 or more): skin cancer, surgical complications, cognition, blood pressure, depression, and ability to work. We identified 5 themes: capacity to control and inevitability, personal relevance, debilitating repercussions, gaining awareness of risks, and addressing knowledge gaps. Conclusions. Graft complications and severe comorbidities were critically important for both stakeholder groups. These stakeholderprioritized outcomes will inform the core outcome set to improve the consistency and relevance of trials in kidney transplantation.
Keywords: Humans; Kidney Transplantation; Consensus; Delphi Technique; Adolescent; Adult; Aged; Middle Aged; Caregivers; Health Personnel; Outcome Assessment (Health Care); Clinical Trials as Topic; Young Adult; Surveys and Questionnaires
Rights: Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
RMID: 0030073482
DOI: 10.1097/TP.0000000000001776
Grant ID: http://purl.org/au-research/grants/nhmrc/1128564
http://purl.org/au-research/grants/nhmrc/1092957
http://purl.org/au-research/grants/nhmrc/1106716
Appears in Collections:Medicine publications

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