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https://hdl.handle.net/2440/111740
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Type: | Journal article |
Title: | Young-onset colorectal cancer in New South Wales: a population-based study |
Author: | Boyce, S. Nassar, N. Lee, C. Suen, M. Zahrani, S. Gladman, M. |
Citation: | Medical Journal of Australia, 2016; 205(10):465-470 |
Publisher: | Australasian Medical Publishing Company |
Issue Date: | 2016 |
ISSN: | 0025-729X 1326-5377 |
Statement of Responsibility: | Stephen Boyce, Natasha Nassar, Cathy Yuen Yi Lee, Michael KL Suen, Saleh Al Zahrani, Marc A Gladman |
Abstract: | Objective: Australia has the highest incidence of colorectal cancer (CRC) in the world. The incidence of young-onset CRC (yCRC) is increasing in developed nations. Our aim was to determine the incidence of yCRC in New South Wales, the demographic and clinico-pathological characteristics of these patients, and their survival. Design, setting, participants: A population-based cohort study of all cases of CRC diagnosed in NSW during 2001-2008. Data on newly diagnosed cases of CRC were obtained from the NSW Central Cancer Registry; mortality data were obtained from the NSW Registry of Births Deaths and Marriages (to 2012). The characteristics and tumour-related factors of patients under 50 years of age (yCRC) were compared with those for patients aged 50 years or more. Main outcome measures: Current incidence of yCRC and trends in incidence; 5-year cancer-specific survival rates and risks of death compared with older patients. Results: 32 178 patients were diagnosed with CRC, including 2001 (6.2%) with yCRC. The incidence of yCRC was unchanged across the study period (2001, 13.7 cases per 100 000 population; 2008, 11.8 per 100 000; P = 0.26). Rectal cancer was more frequent in yCRC than in older patients (34.4% v 26.0%), as was distant disease (21.2% v 15.3%). However, 5-year cancer-specific survival was greater for patients with yCRC (68.8%; 95% CI, 66.2-71.2%) than for older patients (66.3%; 95% CI, 65.6-67.0%; P < 0.001). Conclusions: The incidence of yCRC did not increase in NSW during 2001-2008. Despite more advanced disease at presentation, cancer-specific survival was better than for older patients with CRC. |
Keywords: | Humans Colorectal Neoplasms Mass Screening Registries Incidence Survival Rate Multivariate Analysis Proportional Hazards Models Cohort Studies Age of Onset Adult Aged Aged, 80 and over Middle Aged New South Wales Female Male Kaplan-Meier Estimate |
Rights: | © 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. |
DOI: | 10.5694/mja16.00237 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1067066 |
Published version: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84996490868&doi=10.5694/mja16.00237&partnerID=40&md5=1c44a15bf895d0d9966b695e17d3e29a |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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