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Type: Journal article
Title: Musculoskeletal health in the context of spinal cord injury
Author: Clark, J.
Findlay, D.
Citation: Current Osteoporosis Reports, 2017; 15(5):433-442
Publisher: Springer
Issue Date: 2017
ISSN: 1544-1873
Statement of
Jillian M. Clark, David M. Findlay
Abstract: Purpose of Review: This review assembles recent understanding of the profound loss of muscle and bone in spinal cord injury (SCI). It is important to try to understand these changes, and the context in which they occur, because of their impact on the wellbeing of SC-injured individuals, and the urgent need for viable preventative therapies. Recent Findings: Recent research provides new understanding of the effects of age and systemic factors on the response of bone to loading, of relevance to attempts to provide load therapy for bone in SCI. The rapidly growing dataset describing the biochemical crosstalk between bone and muscle, and the cell and molecular biology of myokines signalling to bone and osteokines regulating muscle metabolism and mass, is reviewed. The ways in which this crosstalk may be altered in SCI is summarised. Summary: Therapeutic approaches to the catabolic changes in muscle and bone in SCI require a holistic understanding of their unique mechanical and biochemical context.
Keywords: Spinal cord injury; bone; muscle; bone loading; myokines; osteokines
Rights: © Springer Science+Business Media, LLC 2017
RMID: 0030074866
DOI: 10.1007/s11914-017-0400-1
Appears in Collections:Medicine publications

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