Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/124136
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Type: | Journal article |
Title: | Omega-3 fatty acid supplementation in pregnancy - baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial |
Author: | Simmonds, L.A. Sullivan, T.R. Skubisz, M. Middleton, P.F. Best, K.P. Yelland, L.N. Quinlivan, J. Zhou, S.J. Liu, G. McPhee, A.J. Gibson, R.A. Makrides, M. |
Citation: | BJOG: an International Journal of Obstetrics and Gynaecology, 2020; 127(8):975-981 |
Publisher: | Wiley |
Issue Date: | 2020 |
ISSN: | 1470-0328 1471-0528 |
Statement of Responsibility: | LA Simmonds, TR Sullivan, M Skubisz, PF Middleton, KP Best ... et al. |
Abstract: | OBJECTIVE: To identify a polyunsaturated fatty acid (PUFA) biomarker able to detect which women with singleton pregnancies are most likely to benefit from omega-3 supplementation to reduce their risk of early preterm birth. DESIGN: Exploratory analysis of a randomised controlled trial. SETTING: Six Australian hospitals. POPULATION: Women with a singleton pregnancy enrolled in the ORIP trial. METHODS: Using maternal capillary whole blood collected ~14 weeks' gestation, the fatty acids in total blood lipids were quantified using gas chromatography. Interaction tests examined whether baseline PUFA status modified the effect of omega-3 supplementation on birth outcomes. MAIN OUTCOME MEASURE: Early preterm birth (<34 weeks' gestation). RESULTS: A low total omega-3 PUFA status in early pregnancy was associated with a higher risk of early preterm birth. Among women with a total omega-3 status ≤4.1% of total fatty acids, omega-3 supplementation substantially reduced the risk of early preterm birth compared with control (0.73% vs. 3.16%; relative risk=0.23, 95% CI 0.07-0.79). Conversely, women with higher total omega-3 status in early pregnancy were at lower risk of early preterm birth. Supplementing women with a baseline status above 4.9% increased early preterm birth (2.20% vs. 0.97%; relative risk=2.27, 95% CI 1.13-4.58). CONCLUSIONS: Women with singleton pregnancies and low total omega-3 PUFA status early in pregnancy have an increased risk of early preterm birth and are most likely to benefit from omega-3 supplementation to reduce this risk. Women with higher total omega-3 status are at lower risk and additional omega-3 supplementation may increase their risk. |
Keywords: | Omega-3 fatty acids biomarker docosahexaenoic acid preterm birth |
Description: | First published:08 February 2020 |
Rights: | © 2020 Royal College of Obstetricians and Gynaecologists |
DOI: | 10.1111/1471-0528.16168 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1050468 http://purl.org/au-research/grants/nhmrc/1052388 http://purl.org/au-research/grants/nhmrc/1046207 http://purl.org/au-research/grants/nhmrc/1061704 |
Published version: | http://dx.doi.org/10.1111/1471-0528.16168 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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