Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/128451
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dc.contributor.author | Reichelt, A.C. | - |
dc.contributor.author | Hare, D.J. | - |
dc.contributor.author | Bussey, T.J. | - |
dc.contributor.author | Saksida, L.M. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Trends in Neurosciences, 2019; 42(7):458-470 | - |
dc.identifier.issn | 0166-2236 | - |
dc.identifier.issn | 1878-108X | - |
dc.identifier.uri | http://hdl.handle.net/2440/128451 | - |
dc.description.abstract | The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins. | - |
dc.description.statementofresponsibility | Amy C. Reichelt, Dominic J. Hare, Timothy J. Bussey, and Lisa M. Saksida | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2019 Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.tins.2019.04.003 | - |
dc.subject | Neuroprotection | - |
dc.title | Perineuronal nets: plasticity, protection, and therapeutic potential | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.tins.2019.04.003 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP180101974 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1122981 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Reichelt, A.C. [0000-0002-0637-0411] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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