Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/128451
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dc.contributor.authorReichelt, A.en
dc.contributor.authorHare, D.en
dc.contributor.authorBussey, T.en
dc.contributor.authorSaksida, L.en
dc.date.issued2019en
dc.identifier.citationTrends in Neurosciences, 2019; 42(7):458-470en
dc.identifier.issn0166-2236en
dc.identifier.issn1878-108Xen
dc.identifier.urihttp://hdl.handle.net/2440/128451-
dc.description.abstractThe relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins.en
dc.description.statementofresponsibilityAmy C. Reichelt, Dominic J. Hare, Timothy J. Bussey, and Lisa M. Saksidaen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2019 Elsevier Ltd. All rights reserved.en
dc.subjectNeuroprotectionen
dc.titlePerineuronal nets: plasticity, protection, and therapeutic potentialen
dc.typeJournal articleen
dc.identifier.rmid1000025735en
dc.identifier.doi10.1016/j.tins.2019.04.003en
dc.relation.granthttp://purl.org/au-research/grants/arc/DP180101974en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1122981en
dc.identifier.pubid546458-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidReichelt, A. [0000-0002-0637-0411]en
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